biostudies-literatureGarcia-Pavia PBritish Heart FoundationBritish Heart Foundation Intermediate Clinical Research FellowshipInstituto de Salud Carlos IIINIA NIH HHSNHLBI NIH HHSNational Institutes of Health1554-1568https://www.ebi.ac.uk/biostudies/studies/S-EPMC8060056biostudies-literatureUnknown42(16)Cardiac amyloidosis is a serious and progressive infiltrative disease that is caused by the deposition of amyloid fibrils at the cardiac level. It can be due to rare genetic variants in the hereditary forms or as a consequence of acquired conditions. Thanks to advances in imaging techniques and the possibility of achieving a non-invasive diagnosis, we now know that cardiac amyloidosis is a more frequent disease than traditionally considered. In this position paper the Working Group on Myocardial and Pericardial Disease proposes an invasive and non-invasive definition of cardiac amyloidosis, addresses clinical scenarios and situations to suspect the condition and proposes a diagnostic algorithm to aid diagnosis. Furthermore, we also review how to monitor and treat cardiac amyloidosis, in anEuropean heart journalDiagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases.PMC8060056R01 HL139671PI20/01379PI18/0765FS/18/21/33447R01HL139671-01K24 AG036778R21 AG058348R21AG058348K24AG036778Merlini GBurazor IGrogan MCaforio ALPEriksson UGarcia-Pavia PMaurer MSGonzalez-Lopez EPankuweit SRapezzi CDamy TFontana MKristen AVGillmore JDLinhart AAdler YKindermann IRigopoulos AGBasso CHeymans SImazio MArad MBrucato APantazis AfalseDiagnosis and treatment of cardiac amyloidosis: a position statement of the ESC Working Group on Myocardial and Pericardial Diseases.Cardiac amyloidosis is a serious and progressive infiltrative disease that is caused by the deposition of amyloid fibrils at the cardiac level. It can be due to rare genetic variants in the hereditary forms or as a consequence of acquired conditions. Thanks to advances in imaging techniques and the possibility of achieving a non-invasive diagnosis, we now know that cardiac amyloidosis is a more frequent disease than traditionally considered. In this position paper the Working Group on Myocardial and Pericardial Disease proposes an invasive and non-invasive definition of cardiac amyloidosis, addresses clinical scenarios and situations to suspect the condition and proposes a diagnostic algorithm to aid diagnosis. Furthermore, we also review how to monitor and treat cardiac amyloidosis, in an2021-01-01T00:00:00Z2021 Apr2025-04-04T10:16:18.138Z2025-04-04T10:16:18.138ZS-EPMC80600563382585310.1093/eurheartj/ehab072