{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sobel J"],"funding":["Swiss National Science Foundation"],"pagination":["8800"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8062533"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["Glucose-induced insulin secretion, a hallmark of mature β-cells, is achieved after birth and is preceded by a phase of intense proliferation. These events occurring in the neonatal period are decisive for establishing an appropriate functional β-cell mass that provides the required insulin throughout life. However, key regulators of gene expression involved in functional maturation of β-cells remain to be elucidated. Here, we addressed this issue by mapping open chromatin regions in newborn versus adult rat islets using the ATAC-seq assay. We obtained a genome-wide picture of chromatin accessible sites (~ 100,000) among which 20% were differentially accessible during maturation. An enrichment analysis of transcription factor binding sites identified a group of transcription factors that co"],"journal":["Scientific reports"],"pubmed_title":["Scrt1, a transcriptional regulator of β-cell proliferation identified by differential chromatin accessibility during islet maturation."],"pmcid":["PMC8062533"],"funding_grant_id":["169480","188447","310030"],"pubmed_authors":["Jacovetti C","Sobel J","Regazzi R","Menoud V","Stoll L","Elhanani O","Guay C","Rodriguez-Trejo A","Walker MD"],"additional_accession":[]},"is_claimable":false,"name":"Scrt1, a transcriptional regulator of β-cell proliferation identified by differential chromatin accessibility during islet maturation.","description":"Glucose-induced insulin secretion, a hallmark of mature β-cells, is achieved after birth and is preceded by a phase of intense proliferation. These events occurring in the neonatal period are decisive for establishing an appropriate functional β-cell mass that provides the required insulin throughout life. However, key regulators of gene expression involved in functional maturation of β-cells remain to be elucidated. Here, we addressed this issue by mapping open chromatin regions in newborn versus adult rat islets using the ATAC-seq assay. We obtained a genome-wide picture of chromatin accessible sites (~ 100,000) among which 20% were differentially accessible during maturation. An enrichment analysis of transcription factor binding sites identified a group of transcription factors that co","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2026-05-08T06:15:52.745Z","creation":"2022-02-09T16:08:27.903Z"},"accession":"S-EPMC8062533","cross_references":{"pubmed":["33888791"],"doi":["10.1038/s41598-021-88003-2"]}}