{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["106(5)"],"submitter":["Sasako T"],"funding":["Ministry of Health, Labour and Welfare of Japan","Japan Agency for Medical Research and Development","Manpei Suzuki Diabetes Foundation","Japan Diabetes Society"],"pubmed_abstract":["<h4>Aims</h4>To evaluate the effects of an intensified multifactorial intervention and patient characteristics on the incidence of fractures comorbid with type 2 diabetes.<h4>Methods</h4>Fracture events were identified and analyzed among adverse events reported in the J-DOIT3 study, a multicenter, open-label, randomized, parallel-group trial that was conducted in Japan, in which patients with type 2 diabetes were randomly assigned to receive conventional therapy for glucose, blood pressure, and lipids (targets: HbA1c < 6.9%, blood pressure <130/80 mm Hg, LDL-cholesterol <120mg/dL) or intensive therapy (HbA1c < 6.2%, blood pressure <120/75 mm Hg, LDL-cholesterol <80mg/dL) (ClinicalTrials.gov registration no. NCT00300976).<h4>Results</h4>The cumulative incidence of fractures did not differ b"],"journal":["The Journal of clinical endocrinology and metabolism"],"pagination":["e2116-e2128"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8063245"],"repository":["biostudies-literature"],"pubmed_title":["Effect of a Multifactorial Intervention on Fracture in Patients With Type 2 Diabetes: Subanalysis of the J-DOIT3 Study."],"pmcid":["PMC8063245"],"pubmed_authors":["Sasako T","Okazaki Y","Ueki K","Miyake K","Ohashi Y","Kadowaki T","Takeuchi Y","Noda M"],"additional_accession":[]},"is_claimable":false,"name":"Effect of a Multifactorial Intervention on Fracture in Patients With Type 2 Diabetes: Subanalysis of the J-DOIT3 Study.","description":"<h4>Aims</h4>To evaluate the effects of an intensified multifactorial intervention and patient characteristics on the incidence of fractures comorbid with type 2 diabetes.<h4>Methods</h4>Fracture events were identified and analyzed among adverse events reported in the J-DOIT3 study, a multicenter, open-label, randomized, parallel-group trial that was conducted in Japan, in which patients with type 2 diabetes were randomly assigned to receive conventional therapy for glucose, blood pressure, and lipids (targets: HbA1c < 6.9%, blood pressure <130/80 mm Hg, LDL-cholesterol <120mg/dL) or intensive therapy (HbA1c < 6.2%, blood pressure <120/75 mm Hg, LDL-cholesterol <80mg/dL) (ClinicalTrials.gov registration no. NCT00300976).<h4>Results</h4>The cumulative incidence of fractures did not differ b","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-03T21:04:15.586Z","creation":"2022-02-11T14:14:37.959Z"},"accession":"S-EPMC8063245","cross_references":{"pubmed":["33491087"],"doi":["10.1210/clinem/dgab013"]}}