biostudies-literaturePaul PThe Danish Cancer SocietyNCI NIH HHSNational Institutes of Health1423-1432https://www.ebi.ac.uk/biostudies/studies/S-EPMC8064050biostudies-literatureUnknown223(8)<h4>Background</h4>Understanding the source of newly detected human papillomavirus (HPV) in middle-aged women is important to inform preventive strategies, such as screening and HPV vaccination.<h4>Methods</h4>We conducted a prospective cohort study in Baltimore, Maryland. Women aged 35-60 years underwent HPV testing and completed health and sexual behavior questionnaires every 6 months over a 2-year period. New detection/loss of detection rates were calculated and adjusted hazard ratios were used to identify risk factors for new detection.<h4>Results</h4>The new and loss of detection analyses included 731 women, and 104 positive for high-risk HPV. The rate of new high-risk HPV detection was 5.0 per 1000 woman-months. Reporting a new sex partner was associated with higher detection rates (The Journal of infectious diseasesRates of New Human Papillomavirus Detection and Loss of Detection in Middle-aged Women by Recent and Past Sexual Behavior.PMC8064050R01 CA123467R146-A9524R200-A12132R01CA123467Gravitt PERositch AFSilver MIYouk AOHammer AViscidi RPPaul PBurke AECampos NfalseRates of New Human Papillomavirus Detection and Loss of Detection in Middle-aged Women by Recent and Past Sexual Behavior.<h4>Background</h4>Understanding the source of newly detected human papillomavirus (HPV) in middle-aged women is important to inform preventive strategies, such as screening and HPV vaccination.<h4>Methods</h4>We conducted a prospective cohort study in Baltimore, Maryland. Women aged 35-60 years underwent HPV testing and completed health and sexual behavior questionnaires every 6 months over a 2-year period. New detection/loss of detection rates were calculated and adjusted hazard ratios were used to identify risk factors for new detection.<h4>Results</h4>The new and loss of detection analyses included 731 women, and 104 positive for high-risk HPV. The rate of new high-risk HPV detection was 5.0 per 1000 woman-months. Reporting a new sex partner was associated with higher detection rates (2021-01-01T00:00:00Z2021 Apr2025-04-04T11:00:57.788Z2022-02-11T12:02:47.431ZS-EPMC80640503287098210.1093/infdis/jiaa557