{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lorenzatti Hiles G"],"funding":["Ministry of Science and Technology, Taiwan","National Cancer Institute at the National Institutes of Health","Chang Gung Memorial Hospital","University of Michigan Undergraduate Research Opportunity Program","NCI NIH HHS","University of Michigan-Chang Gung Memorial Hospital Pilot Grant"],"pagination":["e0250530"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8064583"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(4)"],"pubmed_abstract":["<h4>Background and objectives</h4>Human papillomavirus (HPV)-driven oropharyngeal squamous cell carcinoma (OPSCC) is increasing globally. In Taiwan, HPV-positive OPSCC is obscured by tobacco, alcohol, and betel quid use. We investigated the role of high-risk HPV (hrHPV) in a large retrospective Taiwan OPSCC cohort.<h4>Methods and results</h4>The cohort of 541 OPSCCs treated at Chang Gung Memorial Hospital from 1998-2016 consisted of 507 men (94%) and 34 women (6%). Most used tobacco (81%), alcohol (51%), and betel quid (65%). Formalin-fixed, paraffin-embedded tissue was used for p16 staining (a surrogate marker for HPV) and testing for HPV DNA presence and type by Multiplex HPV PCR-MassArray. HPV DNA and/or p16 staining (HPV-positive) was found in 28.4% (150/528) tumors. p16 and HPV DNA we"],"journal":["PloS one"],"pubmed_title":["Understanding the impact of high-risk human papillomavirus on oropharyngeal squamous cell carcinomas in Taiwan: A retrospective cohort study."],"pmcid":["PMC8064583"],"funding_grant_id":["CORPG3G0171","CMRPG3H0852","MOST 108-2314-B-182A-108-MY3","CMRPG3J1251","R01 CA194536","CA194536","CA194536-S1"],"pubmed_authors":["Wang CI","Pinatti LM","Walline HM","Thomas TB","Goudsmit CM","Chang KP","Yen WC","Afsari MA","Carey TE","Bellile EL","Morris AC","Briggs HL","Peters L","Jawad N","Lorenzatti Hiles G"],"additional_accession":[]},"is_claimable":false,"name":"Understanding the impact of high-risk human papillomavirus on oropharyngeal squamous cell carcinomas in Taiwan: A retrospective cohort study.","description":"<h4>Background and objectives</h4>Human papillomavirus (HPV)-driven oropharyngeal squamous cell carcinoma (OPSCC) is increasing globally. In Taiwan, HPV-positive OPSCC is obscured by tobacco, alcohol, and betel quid use. We investigated the role of high-risk HPV (hrHPV) in a large retrospective Taiwan OPSCC cohort.<h4>Methods and results</h4>The cohort of 541 OPSCCs treated at Chang Gung Memorial Hospital from 1998-2016 consisted of 507 men (94%) and 34 women (6%). Most used tobacco (81%), alcohol (51%), and betel quid (65%). Formalin-fixed, paraffin-embedded tissue was used for p16 staining (a surrogate marker for HPV) and testing for HPV DNA presence and type by Multiplex HPV PCR-MassArray. HPV DNA and/or p16 staining (HPV-positive) was found in 28.4% (150/528) tumors. p16 and HPV DNA we","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-06-03T19:27:08.434Z","creation":"2025-02-19T03:49:18.342Z"},"accession":"S-EPMC8064583","cross_references":{"pubmed":["33891627"],"doi":["10.1371/journal.pone.0250530"]}}