biostudies-literatureDeantoni MExcellence of ScienceFonds De La Recherche Scientifique - FNRS476https://www.ebi.ac.uk/biostudies/studies/S-EPMC8069225biostudies-literatureUnknown11(4)Continuation of experience-dependent neural activity during offline sleep and wakefulness episodes is a critical component of memory consolidation. Using functional magnetic resonance imaging (fMRI), offline consolidation effects have been evidenced probing behavioural and neurophysiological changes during memory retrieval, i.e., in the context of task practice. Resting state fMRI (rsfMRI) further allows investigating the offline evolution of recently learned information without the confounds of online task-related effects. We used rsfMRI to investigate sleep-related changes in seed-based resting functional connectivity (FC) and amplitude of low frequency fluctuations (ALFF) after spatial navigation learning and relearning. On Day 1, offline resting state activity was measured immediately Brain sciencesPost-Training Sleep Modulates Topographical Relearning-Dependent Resting State Activity.PMC8069225304461997020836Balteau EDeantoni MVillemonteix TSchmidt CPeigneux PfalsePost-Training Sleep Modulates Topographical Relearning-Dependent Resting State Activity.Continuation of experience-dependent neural activity during offline sleep and wakefulness episodes is a critical component of memory consolidation. Using functional magnetic resonance imaging (fMRI), offline consolidation effects have been evidenced probing behavioural and neurophysiological changes during memory retrieval, i.e., in the context of task practice. Resting state fMRI (rsfMRI) further allows investigating the offline evolution of recently learned information without the confounds of online task-related effects. We used rsfMRI to investigate sleep-related changes in seed-based resting functional connectivity (FC) and amplitude of low frequency fluctuations (ALFF) after spatial navigation learning and relearning. On Day 1, offline resting state activity was measured immediately 2021-01-01T00:00:00Z2021 Apr2025-04-18T23:14:31.961Z2025-04-07T10:51:33.35ZS-EPMC80692253391857410.3390/brainsci11040476