biostudies-literatureUnknown9(4)Colomer MAWe developed an agent-based stochastic model, based on P Systems methodology, to decipher the effects of vaccination and contact tracing on the control of COVID-19 outbreak at population level under different control measures (social distancing, mask wearing and hand hygiene) and epidemiological scenarios. Our findings suggest that without the application of protection social measures, 56.1% of the Spanish population would contract the disease with a mortality of 0.4%. Assuming that 20% of the population was protected by vaccination by the end of the summer of 2021, it would be expected that 45% of the population would contract the disease and 0.3% of the population would die. However, both of these percentages are significantly lower when social measures were adopted, being the best resulVaccines386https://www.ebi.ac.uk/biostudies/studies/S-EPMC8071008biostudies-literatureModeling of Vaccination and Contact Tracing as Tools to Control the COVID-19 Outbreak in Spain.PMC8071008Vilella AFraile LColomer MAAlos FOliva-Vidal PMargalida AfalseModeling of Vaccination and Contact Tracing as Tools to Control the COVID-19 Outbreak in Spain.We developed an agent-based stochastic model, based on P Systems methodology, to decipher the effects of vaccination and contact tracing on the control of COVID-19 outbreak at population level under different control measures (social distancing, mask wearing and hand hygiene) and epidemiological scenarios. Our findings suggest that without the application of protection social measures, 56.1% of the Spanish population would contract the disease with a mortality of 0.4%. Assuming that 20% of the population was protected by vaccination by the end of the summer of 2021, it would be expected that 45% of the population would contract the disease and 0.3% of the population would die. However, both of these percentages are significantly lower when social measures were adopted, being the best resul2021-01-01T00:00:00Z2021 Apr2025-04-18T14:06:18.58Z2022-02-10T10:40:27.389ZS-EPMC80710083392002710.3390/vaccines9040386