{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Mifsud NA"],"pubmed_abstract":["Antiseizure medications (ASMs) are frequently implicated in T cell-mediated drug hypersensitivity reactions and cause skin tropic pathologies that range in severity from mild rashes to life-threatening systemic syndromes. During the acute stages of the more severe manifestations of these reactions, drug responsive proinflammatory CD8<sup>+</sup> T cells display classical features of Th1 cytokine production (<i>e.g.</i> IFNγ) and cytolysis (<i>e.g.</i> granzyme B, perforin). These T cells may be found locally at the site of pathology (<i>e.g.</i> blister cells/fluid), as well as systemically (<i>e.g.</i> blood, organs). What is less understood are the long-lived immunological effects of the memory T cell pool following T cell-mediated drug hypersensitivity reactions. In this study, we exami"],"journal":["Frontiers in immunology"],"pagination":["653710"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8071863"],"repository":["biostudies-literature"],"pubmed_title":["Carbamazepine Induces Focused T Cell Responses in Resolved Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Cases But Does Not Perturb the Immunopeptidome for T Cell Recognition."],"pmcid":["PMC8071863"],"pubmed_authors":["Purcell AW","Mifsud NA","Hensen L","Huang Z","Illing PT","Rossjohn J","Vivian JP","Lai JW","Fettke H","Kwan P"],"additional_accession":[]},"is_claimable":false,"name":"Carbamazepine Induces Focused T Cell Responses in Resolved Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Cases But Does Not Perturb the Immunopeptidome for T Cell Recognition.","description":"Antiseizure medications (ASMs) are frequently implicated in T cell-mediated drug hypersensitivity reactions and cause skin tropic pathologies that range in severity from mild rashes to life-threatening systemic syndromes. During the acute stages of the more severe manifestations of these reactions, drug responsive proinflammatory CD8<sup>+</sup> T cells display classical features of Th1 cytokine production (<i>e.g.</i> IFNγ) and cytolysis (<i>e.g.</i> granzyme B, perforin). These T cells may be found locally at the site of pathology (<i>e.g.</i> blister cells/fluid), as well as systemically (<i>e.g.</i> blood, organs). What is less understood are the long-lived immunological effects of the memory T cell pool following T cell-mediated drug hypersensitivity reactions. In this study, we exami","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-04-07T16:50:30.576Z","creation":"2022-02-10T08:19:55.854Z"},"accession":"S-EPMC8071863","cross_references":{"pubmed":["33912179"],"doi":["10.3389/fimmu.2021.653710"]}}