biostudies-literatureUnknown12Mifsud NAAntiseizure medications (ASMs) are frequently implicated in T cell-mediated drug hypersensitivity reactions and cause skin tropic pathologies that range in severity from mild rashes to life-threatening systemic syndromes. During the acute stages of the more severe manifestations of these reactions, drug responsive proinflammatory CD8⁺ T cells display classical features of Th1 cytokine production (<i>e.g.</i> IFNγ) and cytolysis (<i>e.g.</i> granzyme B, perforin). These T cells may be found locally at the site of pathology (<i>e.g.</i> blister cells/fluid), as well as systemically (<i>e.g.</i> blood, organs). What is less understood are the long-lived immunological effects of the memory T cell pool following T cell-mediated drug hypersensitivity reactions. In this study, we examiFrontiers in immunology653710https://www.ebi.ac.uk/biostudies/studies/S-EPMC8071863biostudies-literatureCarbamazepine Induces Focused T Cell Responses in Resolved Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Cases But Does Not Perturb the Immunopeptidome for T Cell Recognition.PMC8071863Purcell AWMifsud NAHensen LHuang ZIlling PTRossjohn JVivian JPLai JWFettke HKwan PfalseCarbamazepine Induces Focused T Cell Responses in Resolved Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Cases But Does Not Perturb the Immunopeptidome for T Cell Recognition.Antiseizure medications (ASMs) are frequently implicated in T cell-mediated drug hypersensitivity reactions and cause skin tropic pathologies that range in severity from mild rashes to life-threatening systemic syndromes. During the acute stages of the more severe manifestations of these reactions, drug responsive proinflammatory CD8⁺ T cells display classical features of Th1 cytokine production (<i>e.g.</i> IFNγ) and cytolysis (<i>e.g.</i> granzyme B, perforin). These T cells may be found locally at the site of pathology (<i>e.g.</i> blister cells/fluid), as well as systemically (<i>e.g.</i> blood, organs). What is less understood are the long-lived immunological effects of the memory T cell pool following T cell-mediated drug hypersensitivity reactions. In this study, we exami2021-01-01T00:00:00Z20212026-04-07T16:50:30.576Z2022-02-10T08:19:55.854ZS-EPMC80718633391217910.3389/fimmu.2021.653710