{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Liu Y"],"funding":["Wu Jieping Medical Foundation","Natural Science Foundation of Shanghai"],"pubmed_abstract":["Interleukin (IL)-35-secreting B (IL-35+B) cells are critical regulators in autoimmune and infectious diseases and exert suppressive functions in parallel with IL-10-producing B (B10) cells. However, the role of IL-35+B cells in persistent hepatitis B virus (HBV) infection remains unclear. To elucidate the role of IL-35+B cells in the progress of chronic HBV infection, we determined the frequency of IL-35+B cells and their relationship with the classical human regulatory B cell (Breg) subsets, namely, CD19+CD24<sup>hi</sup>CD38<sup>hi</sup> and CD19+CD24<sup>hi</sup>CD27+. Then, the regulatory effect and mechanism of Bregs on effector T cells were investigated <i>in vitro</i>. Here, we found that compared with healthy controls, the frequency of IL-35+B cells was increased in patients with c"],"journal":["Frontiers in immunology"],"pagination":["653198"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8072152"],"repository":["biostudies-literature"],"pubmed_title":["Regulatory B Cells Dysregulated T Cell Function in an IL-35-Dependent Way in Patients With Chronic Hepatitis B."],"pmcid":["PMC8072152"],"pubmed_authors":["Tian Z","Liu Y","Liang X","Luo Y","Jiang M","Tang G","Zhu T"],"additional_accession":[]},"is_claimable":false,"name":"Regulatory B Cells Dysregulated T Cell Function in an IL-35-Dependent Way in Patients With Chronic Hepatitis B.","description":"Interleukin (IL)-35-secreting B (IL-35+B) cells are critical regulators in autoimmune and infectious diseases and exert suppressive functions in parallel with IL-10-producing B (B10) cells. However, the role of IL-35+B cells in persistent hepatitis B virus (HBV) infection remains unclear. To elucidate the role of IL-35+B cells in the progress of chronic HBV infection, we determined the frequency of IL-35+B cells and their relationship with the classical human regulatory B cell (Breg) subsets, namely, CD19+CD24<sup>hi</sup>CD38<sup>hi</sup> and CD19+CD24<sup>hi</sup>CD27+. Then, the regulatory effect and mechanism of Bregs on effector T cells were investigated <i>in vitro</i>. Here, we found that compared with healthy controls, the frequency of IL-35+B cells was increased in patients with c","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-03T09:06:10.866Z","creation":"2022-02-10T08:21:47.739Z"},"accession":"S-EPMC8072152","cross_references":{"pubmed":["33912178"],"doi":["10.3389/fimmu.2021.653198"]}}