biostudies-literatureDi Sapia RCitizens United for Research in EpilepsyDefense Health Agency76https://www.ebi.ac.uk/biostudies/studies/S-EPMC8073903biostudies-literatureUnknown9(1)Post-traumatic epilepsy (PTE) accounts for 5% of all epilepsies and 10-20% of the acquired forms. The latency between traumatic brain injury (TBI) and epilepsy onset in high-risk patients offers a therapeutic window for intervention to prevent or improve the disease course. However, progress towards effective treatments has been hampered by the lack of sensitive prognostic biomarkers of PTE, and of therapeutic targets. There is therefore a pressing clinical need for preclinical PTE models suitable for biomarker discovery and drug testing. We characterized in-depth a model of severe TBI induced by controlled cortical impact evolving into PTE in CD1 adult male mice. To identify sensitive measures predictive of PTE development and severity, TBI mice were longitudinally monitored by video-elecActa neuropathologica communicationsIn-depth characterization of a mouse model of post-traumatic epilepsy for biomarker and drug discovery.PMC8073903W81XWH-19-1-0733W81XWH-15-2-0069Iori VZanier ERMontanarella MMoro FWang KKWMicotti ERavizza TVezzani ATolomeo DDi Sapia RfalseIn-depth characterization of a mouse model of post-traumatic epilepsy for biomarker and drug discovery.Post-traumatic epilepsy (PTE) accounts for 5% of all epilepsies and 10-20% of the acquired forms. The latency between traumatic brain injury (TBI) and epilepsy onset in high-risk patients offers a therapeutic window for intervention to prevent or improve the disease course. However, progress towards effective treatments has been hampered by the lack of sensitive prognostic biomarkers of PTE, and of therapeutic targets. There is therefore a pressing clinical need for preclinical PTE models suitable for biomarker discovery and drug testing. We characterized in-depth a model of severe TBI induced by controlled cortical impact evolving into PTE in CD1 adult male mice. To identify sensitive measures predictive of PTE development and severity, TBI mice were longitudinally monitored by video-elec2021-01-01T00:00:00Z2021 Apr2025-04-18T23:11:46.127Z2022-02-09T18:12:04.599ZS-EPMC80739033390268510.1186/s40478-021-01165-y