biostudies-literatureTerada TJapanese Ministry of Education, Culture, Sports, Science and Technology28https://www.ebi.ac.uk/biostudies/studies/S-EPMC8074456biostudies-literatureUnknown16(1)<h4>Background</h4>Mitochondrial electron transport chain abnormalities have been reported in postmortem pathological specimens of Alzheimer's disease (AD). However, it remains unclear how amyloid and tau are associated with mitochondrial dysfunction in vivo. The purpose of this study is to assess the local relationships between mitochondrial dysfunction and AD pathophysiology in mild AD using the novel mitochondrial complex I PET imaging agent [¹⁸F]BCPP-EF.<h4>Methods</h4>Thirty-two amyloid and tau positive mild stage AD dementia patients (mean age ± SD: 71.1 ± 8.3 years) underwent a series of PET measurements with [¹⁸F]BCPP-EF mitochondrial function, [¹¹C]PBB3 for tau deposition, and [¹¹C] PiB for amyloid deposition. Age-matched normal control Molecular neurodegenerationMitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer's disease.PMC807445616H06402A0117H0424717K09797Tsukada HOuchi YRosa-Neto PLussier FBenedet ABunai TTissot CObi TTerada TPascoal TAWang YTMatsudaira TTherriault JKang MSPSavard MfalseMitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer's disease.<h4>Background</h4>Mitochondrial electron transport chain abnormalities have been reported in postmortem pathological specimens of Alzheimer's disease (AD). However, it remains unclear how amyloid and tau are associated with mitochondrial dysfunction in vivo. The purpose of this study is to assess the local relationships between mitochondrial dysfunction and AD pathophysiology in mild AD using the novel mitochondrial complex I PET imaging agent [¹⁸F]BCPP-EF.<h4>Methods</h4>Thirty-two amyloid and tau positive mild stage AD dementia patients (mean age ± SD: 71.1 ± 8.3 years) underwent a series of PET measurements with [¹⁸F]BCPP-EF mitochondrial function, [¹¹C]PBB3 for tau deposition, and [¹¹C] PiB for amyloid deposition. Age-matched normal control 2021-01-01T00:00:00Z2021 Apr2025-04-04T07:47:27.386Z2022-02-09T18:07:49.698ZS-EPMC80744563390265410.1186/s13024-021-00448-1