biostudies-literatureUnknown19(2)Cerit C<h4>Objective</h4>Investigating the molecular basis of bipolar disorder (BD) is crucial in terms of developing effective treatment strategies as well as objective laboratory-based diagnostic tools for the disease.<h4>Methods</h4>We examined the urine samples of BD patients both in manic episode and after remission and compared their urinary protein profiles with the controls. Twelve patients and twelve controls (C group) included to the study. Urinary samples of patients were first collected during manic episode (M group) and then after remission (R group). Two-dimensional gel electrophoresis (2-DE) coupled to MALDI-TOF/TOF massspectrometry approach and Western blot analysis were used.<h4>Results</h4>Alpha-1-microglobulin and bukinin precursor (AMBP), Mannan-binding lectine serin protease-Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology269-281https://www.ebi.ac.uk/biostudies/studies/S-EPMC8077062biostudies-literatureAre Mannan-binding Lectine Serin Protease-2 and Alpha-1-microglobulin and Bukinin Precursor the Potential Biomarkers of Manic Episode? A Study via Urinary Proetomic Analysis.PMC8077062Sarıhan MNart OKasap MAkpınar GYasar HCerit CfalseAre Mannan-binding Lectine Serin Protease-2 and Alpha-1-microglobulin and Bukinin Precursor the Potential Biomarkers of Manic Episode? A Study via Urinary Proetomic Analysis.<h4>Objective</h4>Investigating the molecular basis of bipolar disorder (BD) is crucial in terms of developing effective treatment strategies as well as objective laboratory-based diagnostic tools for the disease.<h4>Methods</h4>We examined the urine samples of BD patients both in manic episode and after remission and compared their urinary protein profiles with the controls. Twelve patients and twelve controls (C group) included to the study. Urinary samples of patients were first collected during manic episode (M group) and then after remission (R group). Two-dimensional gel electrophoresis (2-DE) coupled to MALDI-TOF/TOF massspectrometry approach and Western blot analysis were used.<h4>Results</h4>Alpha-1-microglobulin and bukinin precursor (AMBP), Mannan-binding lectine serin protease-2021-01-01T00:00:00Z2021 May2025-06-01T00:14:39.019Z2025-06-01T00:14:39.019ZS-EPMC80770623388865610.9758/cpn.2021.19.2.269