{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jin H"],"funding":["Natural Science Foundation of China","Wenzhou Science and Technology Bureau","Wenzhou Medical University","Startup Foundation for Hundred-Talent Program of Zhejiang University","Key Discipline of Zhejiang Province in Medical Technology","Key Project of Science and Technology Innovation Team of Zhejiang Province","National Natural Science Foundation of China"],"pagination":["840-854"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8078721"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(4)"],"pubmed_abstract":["Although <i>MIR516A</i> has been reported to be downregulated and act as a tumor suppressor in multiple cancers, its expression and potential contribution to human bladder cancer (BC) remain unexplored. Unexpectedly, we showed here that <i>MIR516A</i> was markedly upregulated in human BC tissues and cell lines, while inhibition of <i>MIR516A</i> expression attenuated BC cell monolayer growth <i>in vitro</i> and xenograft tumor growth <i>in vivo</i>, accompanied with increased expression of PHLPP2. Further studies showed that <i>MIR516A</i> was able to directly bind to the 3'-untranslated region of <i>PHLPP2</i> mRNA, which was essential for its attenuating PHLPP2 expression. The knockdown of <i>PHLPP2</i> expression in <i>MIR516A</i>-inhibited cells could reverse BC cell growth, suggesting"],"journal":["Autophagy"],"pubmed_title":["Oncogenic role of <i>MIR516A</i> in human bladder cancer was mediated by its attenuating PHLPP2 expression and BECN1-dependent autophagy."],"pmcid":["PMC8078721"],"funding_grant_id":["First Class","Category A","2013TD10","Y20170028","2017R413064","Y20190065","NSFC81702530","NSFC81872587","89216021"],"pubmed_authors":["Li H","Huang C","Liu L","Lu Y","Huang H","Chen C","Xie Q","Chang Y","Xu J","Zang N","Tian Z","Zhao N","Jin H","Fang Z","Huang X","Ma J","Wang X"],"additional_accession":[]},"is_claimable":false,"name":"Oncogenic role of <i>MIR516A</i> in human bladder cancer was mediated by its attenuating PHLPP2 expression and BECN1-dependent autophagy.","description":"Although <i>MIR516A</i> has been reported to be downregulated and act as a tumor suppressor in multiple cancers, its expression and potential contribution to human bladder cancer (BC) remain unexplored. Unexpectedly, we showed here that <i>MIR516A</i> was markedly upregulated in human BC tissues and cell lines, while inhibition of <i>MIR516A</i> expression attenuated BC cell monolayer growth <i>in vitro</i> and xenograft tumor growth <i>in vivo</i>, accompanied with increased expression of PHLPP2. Further studies showed that <i>MIR516A</i> was able to directly bind to the 3'-untranslated region of <i>PHLPP2</i> mRNA, which was essential for its attenuating PHLPP2 expression. The knockdown of <i>PHLPP2</i> expression in <i>MIR516A</i>-inhibited cells could reverse BC cell growth, suggesting","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2026-07-09T11:33:30.116Z","creation":"2026-07-09T10:50:51.077Z"},"accession":"S-EPMC8078721","cross_references":{"pubmed":["32116109"],"doi":["10.1080/15548627.2020.1733262"]}}