biostudies-literatureUnknown12Prasad JKThe present study aimed to explore the antimicrobial potentials of soil bacteria and identify the bioactive compounds and their likely targets through <i>in silico</i> studies. A total 53 bacterial isolates were screened for their antimicrobial potential of which the strain JRBHU6 showing highest antimicrobial activity was identified as <i>Burkholderia seminalis</i> (GenBank accession no. MK500868) based on 16S ribosomal RNA (rRNA) gene sequencing and phylogenetic analysis. <i>B. seminalis</i> JRBHU6 also produced hydrolytic enzymes chitinases and cellulase of significance in accrediting its antimicrobial nature. The bioactive metabolites produced by the isolate were extracted in different organic solvents among which methanolic extract showed best growth-suppressing activities toward multFrontiers in microbiology633036https://www.ebi.ac.uk/biostudies/studies/S-EPMC8079638biostudies-literatureDrought Exposed <i>Burkholderia seminalis</i> JRBHU6 Exhibits Antimicrobial Potential Through Pyrazine-1,4-Dione Derivatives Targeting Multiple Bacterial and Fungal Proteins.PMC8079638Anand RPandey PRaghuwanshi RPrasad JKfalseDrought Exposed <i>Burkholderia seminalis</i> JRBHU6 Exhibits Antimicrobial Potential Through Pyrazine-1,4-Dione Derivatives Targeting Multiple Bacterial and Fungal Proteins.The present study aimed to explore the antimicrobial potentials of soil bacteria and identify the bioactive compounds and their likely targets through <i>in silico</i> studies. A total 53 bacterial isolates were screened for their antimicrobial potential of which the strain JRBHU6 showing highest antimicrobial activity was identified as <i>Burkholderia seminalis</i> (GenBank accession no. MK500868) based on 16S ribosomal RNA (rRNA) gene sequencing and phylogenetic analysis. <i>B. seminalis</i> JRBHU6 also produced hydrolytic enzymes chitinases and cellulase of significance in accrediting its antimicrobial nature. The bioactive metabolites produced by the isolate were extracted in different organic solvents among which methanolic extract showed best growth-suppressing activities toward mult2021-01-01T00:00:00Z20212026-04-30T03:09:33.684Z2022-02-10T08:52:14.122ZS-EPMC80796383393599310.3389/fmicb.2021.633036