{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Van Dyke TE"],"funding":["NCATS NIH HHS","NIAID NIH HHS","NHLBI NIH HHS"],"pagination":["348-358"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8080258"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["92(3)"],"pubmed_abstract":["<h4>Background</h4>While growing evidence suggests a link between periodontal disease (PD) and cardiovascular disease (CVD), the independence of this association and the pathway remain unclear. Herein, we tested the hypotheses that: (1) inflammation of the periodontium (PD<sub>inflammation</sub> ) predicts future CVD independently of disease risk factors shared between CVD and PD, and (2) the mechanism linking the two diseases involves heightened arterial inflammation.<h4>Methods</h4><sup>18</sup> F-fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18</sup> F-FDG-PET/CT) imaging was performed in 304 individuals (median age 54 years; 42.4% male) largely for cancer screening; individuals without active cancer were included. PD<sub>inflammation</sub> and arterial inflammation were quantified using validated <sup>18</sup> F-FDG-PET/CT methods. Additionally, we evaluated the relationship between PD<sub>inflammation</sub> and subsequent major adverse cardiovascular events (MACE) using Cox models and log-rank tests.<h4>Results</h4>Thirteen individuals developed MACE during follow-up (median 4.1 years). PD<sub>inflammation</sub> associated with arterial inflammation, remaining significant after adjusting for PD and CVD risk factors (standardized β [95% CI]: 0.30 [0.20-0.40], P < 0.001). PD<sub>inflammation</sub> predicted subsequent MACE (standardized HR [95% CI]: 2.25 [1.47 to 3.44], P <0.001, remaining significant in multivariable models), while periodontal bone loss did not. Furthermore, mediation analysis suggested that arterial inflammation accounts for 80% of the relationship between PD<sub>inflammation</sub> and MACE (standardized log odds ratio [95% CI]: 0.438 [0.019-0.880], P = 0.022).<h4>Conclusion</h4>PD<sub>inflammation</sub> is independently associated with MACE via a mechanism that may involve increased arterial inflammation. These findings provide important support for an independent relationship between PD<sub>inflammation</sub> and CVD."],"journal":["Journal of periodontology"],"pubmed_title":["Inflammation of the periodontium associates with risk of future cardiovascular events."],"pmcid":["PMC8080258"],"funding_grant_id":["T32 HL076136","KL2 TR002542","R01 HL122177","K23 HL151909","R01 HL129856","R01 HL137913","K24 AI112393"],"pubmed_authors":["Abohashem SM","Hsue P","Kholy KE","Ali A","Mezue K","Yuan N","Takx RAP","Tawakol A","Van Dyke TE","Ishai A","Osborne MT"],"additional_accession":[]},"is_claimable":false,"name":"Inflammation of the periodontium associates with risk of future cardiovascular events.","description":"<h4>Background</h4>While growing evidence suggests a link between periodontal disease (PD) and cardiovascular disease (CVD), the independence of this association and the pathway remain unclear. Herein, we tested the hypotheses that: (1) inflammation of the periodontium (PD<sub>inflammation</sub> ) predicts future CVD independently of disease risk factors shared between CVD and PD, and (2) the mechanism linking the two diseases involves heightened arterial inflammation.<h4>Methods</h4><sup>18</sup> F-fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18</sup> F-FDG-PET/CT) imaging was performed in 304 individuals (median age 54 years; 42.4% male) largely for cancer screening; individuals without active cancer were included. PD<sub>inflammation</sub> and arterial inflammation were quantified using validated <sup>18</sup> F-FDG-PET/CT methods. Additionally, we evaluated the relationship between PD<sub>inflammation</sub> and subsequent major adverse cardiovascular events (MACE) using Cox models and log-rank tests.<h4>Results</h4>Thirteen individuals developed MACE during follow-up (median 4.1 years). PD<sub>inflammation</sub> associated with arterial inflammation, remaining significant after adjusting for PD and CVD risk factors (standardized β [95% CI]: 0.30 [0.20-0.40], P < 0.001). PD<sub>inflammation</sub> predicted subsequent MACE (standardized HR [95% CI]: 2.25 [1.47 to 3.44], P <0.001, remaining significant in multivariable models), while periodontal bone loss did not. Furthermore, mediation analysis suggested that arterial inflammation accounts for 80% of the relationship between PD<sub>inflammation</sub> and MACE (standardized log odds ratio [95% CI]: 0.438 [0.019-0.880], P = 0.022).<h4>Conclusion</h4>PD<sub>inflammation</sub> is independently associated with MACE via a mechanism that may involve increased arterial inflammation. These findings provide important support for an independent relationship between PD<sub>inflammation</sub> and CVD.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-19T13:00:51.317Z","creation":"2025-04-19T13:00:51.317Z"},"accession":"S-EPMC8080258","cross_references":{"pubmed":["33512014"],"doi":["10.1002/JPER.19-0441","10.1002/jper.19-0441"]}}