biostudies-literatureVan Dyke TENCATS NIH HHSNIAID NIH HHSNHLBI NIH HHS348-358https://www.ebi.ac.uk/biostudies/studies/S-EPMC8080258biostudies-literatureUnknown92(3)<h4>Background</h4>While growing evidence suggests a link between periodontal disease (PD) and cardiovascular disease (CVD), the independence of this association and the pathway remain unclear. Herein, we tested the hypotheses that: (1) inflammation of the periodontium (PD_inflammation ) predicts future CVD independently of disease risk factors shared between CVD and PD, and (2) the mechanism linking the two diseases involves heightened arterial inflammation.<h4>Methods</h4>¹⁸ F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸ F-FDG-PET/CT) imaging was performed in 304 individuals (median age 54 years; 42.4% male) largely for cancer screening; individuals without active cancer were included. PD_inflammation and arterial inflammation were quantified using validated ¹⁸ F-FDG-PET/CT methods. Additionally, we evaluated the relationship between PD_inflammation and subsequent major adverse cardiovascular events (MACE) using Cox models and log-rank tests.<h4>Results</h4>Thirteen individuals developed MACE during follow-up (median 4.1 years). PD_inflammation associated with arterial inflammation, remaining significant after adjusting for PD and CVD risk factors (standardized β [95% CI]: 0.30 [0.20-0.40], P < 0.001). PD_inflammation predicted subsequent MACE (standardized HR [95% CI]: 2.25 [1.47 to 3.44], P <0.001, remaining significant in multivariable models), while periodontal bone loss did not. Furthermore, mediation analysis suggested that arterial inflammation accounts for 80% of the relationship between PD_inflammation and MACE (standardized log odds ratio [95% CI]: 0.438 [0.019-0.880], P = 0.022).<h4>Conclusion</h4>PD_inflammation is independently associated with MACE via a mechanism that may involve increased arterial inflammation. These findings provide important support for an independent relationship between PD_inflammation and CVD.Journal of periodontologyInflammation of the periodontium associates with risk of future cardiovascular events.PMC8080258T32 HL076136KL2 TR002542R01 HL122177K23 HL151909R01 HL129856R01 HL137913K24 AI112393Abohashem SMHsue PKholy KEAli AMezue KYuan NTakx RAPTawakol AVan Dyke TEIshai AOsborne MTfalseInflammation of the periodontium associates with risk of future cardiovascular events.<h4>Background</h4>While growing evidence suggests a link between periodontal disease (PD) and cardiovascular disease (CVD), the independence of this association and the pathway remain unclear. Herein, we tested the hypotheses that: (1) inflammation of the periodontium (PD_inflammation ) predicts future CVD independently of disease risk factors shared between CVD and PD, and (2) the mechanism linking the two diseases involves heightened arterial inflammation.<h4>Methods</h4>¹⁸ F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸ F-FDG-PET/CT) imaging was performed in 304 individuals (median age 54 years; 42.4% male) largely for cancer screening; individuals without active cancer were included. PD_inflammation and arterial inflammation were quantified using validated ¹⁸ F-FDG-PET/CT methods. Additionally, we evaluated the relationship between PD_inflammation and subsequent major adverse cardiovascular events (MACE) using Cox models and log-rank tests.<h4>Results</h4>Thirteen individuals developed MACE during follow-up (median 4.1 years). PD_inflammation associated with arterial inflammation, remaining significant after adjusting for PD and CVD risk factors (standardized β [95% CI]: 0.30 [0.20-0.40], P < 0.001). PD_inflammation predicted subsequent MACE (standardized HR [95% CI]: 2.25 [1.47 to 3.44], P <0.001, remaining significant in multivariable models), while periodontal bone loss did not. Furthermore, mediation analysis suggested that arterial inflammation accounts for 80% of the relationship between PD_inflammation and MACE (standardized log odds ratio [95% CI]: 0.438 [0.019-0.880], P = 0.022).<h4>Conclusion</h4>PD_inflammation is independently associated with MACE via a mechanism that may involve increased arterial inflammation. These findings provide important support for an independent relationship between PD_inflammation and CVD.2021-01-01T00:00:00Z2021 Mar2025-04-19T13:00:51.317Z2025-04-19T13:00:51.317ZS-EPMC80802583351201410.1002/JPER.19-044110.1002/jper.19-0441