{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mrochen DM"],"funding":["Bundesministerium für Bildung und Forschung","Deutsche Forschungsgemeinschaft"],"pagination":["642802"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8081891"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["Protection against <i>Staphylococcus aureus</i> is determined by the polarization of the anti-bacterial immune effector mechanisms. Virulence factors of <i>S. aureus</i> can modulate these and induce differently polarized immune responses in a single individual. We proposed that this may be due to intrinsic properties of the bacterial proteins. To test this idea, we selected two virulence factors, the serine protease-like protein B (SplB) and the glycerophosphoryl diester phosphodiesterase (GlpQ). In humans naturally exposed to <i>S. aureus</i>, SplB induces a type 2-biased adaptive immune response, whereas GlpQ elicits type 1/type 3 immunity. We injected the recombinant bacterial antigens into the peritoneum of <i>S. aureus</i>-naïve C57BL/6N mice and analyzed the immune response. This wa"],"journal":["Frontiers in immunology"],"pubmed_title":["Immune Polarization Potential of the <i>S. aureus</i> Virulence Factors SplB and GlpQ and Modulation by Adjuvants."],"pmcid":["PMC8081891"],"funding_grant_id":["03ZZ0806B","CRC-TRR34"],"pubmed_authors":["Mrochen DM","Domanska G","Trube P","Broker BM","Jorde I","van den Brandt C"],"additional_accession":[]},"is_claimable":false,"name":"Immune Polarization Potential of the <i>S. aureus</i> Virulence Factors SplB and GlpQ and Modulation by Adjuvants.","description":"Protection against <i>Staphylococcus aureus</i> is determined by the polarization of the anti-bacterial immune effector mechanisms. Virulence factors of <i>S. aureus</i> can modulate these and induce differently polarized immune responses in a single individual. We proposed that this may be due to intrinsic properties of the bacterial proteins. To test this idea, we selected two virulence factors, the serine protease-like protein B (SplB) and the glycerophosphoryl diester phosphodiesterase (GlpQ). In humans naturally exposed to <i>S. aureus</i>, SplB induces a type 2-biased adaptive immune response, whereas GlpQ elicits type 1/type 3 immunity. We injected the recombinant bacterial antigens into the peritoneum of <i>S. aureus</i>-naïve C57BL/6N mice and analyzed the immune response. This wa","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-06T12:54:44.967Z","creation":"2022-02-09T18:09:05.055Z"},"accession":"S-EPMC8081891","cross_references":{"pubmed":["33936060"],"doi":["10.3389/fimmu.2021.642802"]}}