biostudies-literatureMrochen DMBundesministerium für Bildung und ForschungDeutsche Forschungsgemeinschaft642802https://www.ebi.ac.uk/biostudies/studies/S-EPMC8081891biostudies-literatureUnknown12Protection against <i>Staphylococcus aureus</i> is determined by the polarization of the anti-bacterial immune effector mechanisms. Virulence factors of <i>S. aureus</i> can modulate these and induce differently polarized immune responses in a single individual. We proposed that this may be due to intrinsic properties of the bacterial proteins. To test this idea, we selected two virulence factors, the serine protease-like protein B (SplB) and the glycerophosphoryl diester phosphodiesterase (GlpQ). In humans naturally exposed to <i>S. aureus</i>, SplB induces a type 2-biased adaptive immune response, whereas GlpQ elicits type 1/type 3 immunity. We injected the recombinant bacterial antigens into the peritoneum of <i>S. aureus</i>-naïve C57BL/6N mice and analyzed the immune response. This waFrontiers in immunologyImmune Polarization Potential of the <i>S. aureus</i> Virulence Factors SplB and GlpQ and Modulation by Adjuvants.PMC808189103ZZ0806BCRC-TRR34Mrochen DMDomanska GTrube PBroker BMJorde Ivan den Brandt CfalseImmune Polarization Potential of the <i>S. aureus</i> Virulence Factors SplB and GlpQ and Modulation by Adjuvants.Protection against <i>Staphylococcus aureus</i> is determined by the polarization of the anti-bacterial immune effector mechanisms. Virulence factors of <i>S. aureus</i> can modulate these and induce differently polarized immune responses in a single individual. We proposed that this may be due to intrinsic properties of the bacterial proteins. To test this idea, we selected two virulence factors, the serine protease-like protein B (SplB) and the glycerophosphoryl diester phosphodiesterase (GlpQ). In humans naturally exposed to <i>S. aureus</i>, SplB induces a type 2-biased adaptive immune response, whereas GlpQ elicits type 1/type 3 immunity. We injected the recombinant bacterial antigens into the peritoneum of <i>S. aureus</i>-naïve C57BL/6N mice and analyzed the immune response. This wa2021-01-01T00:00:00Z20212025-04-06T12:54:44.967Z2022-02-09T18:09:05.055ZS-EPMC80818913393606010.3389/fimmu.2021.642802