{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mishto M"],"funding":["Cancer Research UK","European Research Council","National Institute for Health Research (NIHR)"],"pagination":["656451"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8082463"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["Increasing evidence suggests that post-translational peptide splicing can play a role in the immune response under pathological conditions. This seems to be particularly relevant in Type 1 Diabetes (T1D) since post-translationally spliced epitopes derived from T1D-associated antigens have been identified among those peptides bound to Human Leucocyte Antigen (HLA) class I and II complexes. Their immunogenicity has been confirmed through CD4<sup>+</sup> and CD8<sup>+</sup> T cell-mediated responses in T1D patients. Spliced peptides theoretically have a large sequence variability. This might increase the frequency of viral-human <i>zwitter</i> peptides<i>, i.e.</i> peptides that share a complete sequence homology irrespective of whether they originate from human or viral antigens, thereby imp"],"journal":["Frontiers in immunology"],"pubmed_title":["Potential Mimicry of Viral and Pancreatic β Cell Antigens Through Non-Spliced and &lt;i&gt;cis&lt;/i&gt;-Spliced &lt;i&gt;Zwitter&lt;/i&gt; Epitope Candidates in Type 1 Diabetes."],"pmcid":["PMC8082463"],"funding_grant_id":["29686","C67500/A29686"],"pubmed_authors":["Mansurkhodzhaev A","Rodriguez-Calvo T","Liepe J","Mishto M"],"additional_accession":[]},"is_claimable":false,"name":"Potential Mimicry of Viral and Pancreatic β Cell Antigens Through Non-Spliced and &lt;i&gt;cis&lt;/i&gt;-Spliced &lt;i&gt;Zwitter&lt;/i&gt; Epitope Candidates in Type 1 Diabetes.","description":"Increasing evidence suggests that post-translational peptide splicing can play a role in the immune response under pathological conditions. This seems to be particularly relevant in Type 1 Diabetes (T1D) since post-translationally spliced epitopes derived from T1D-associated antigens have been identified among those peptides bound to Human Leucocyte Antigen (HLA) class I and II complexes. Their immunogenicity has been confirmed through CD4<sup>+</sup> and CD8<sup>+</sup> T cell-mediated responses in T1D patients. Spliced peptides theoretically have a large sequence variability. This might increase the frequency of viral-human <i>zwitter</i> peptides<i>, i.e.</i> peptides that share a complete sequence homology irrespective of whether they originate from human or viral antigens, thereby imp","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-08T06:04:40.368Z","creation":"2022-02-10T08:55:03.863Z"},"accession":"S-EPMC8082463","cross_references":{"pubmed":["33936085"],"doi":["10.3389/fimmu.2021.656451"]}}