{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mallon PWG"],"funding":["Science Foundation Ireland","European Union’s Horizon 2020 Research and Innovation Programme"],"pagination":["ofab122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8083770"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(8)"],"pubmed_abstract":["Background
Although reports suggest that most individuals with coronavirus disease 2019 (COVID-19) develop detectable antibodies postinfection, the kinetics, durability, and relative differences between immunoglobulin M (IgM) and immunoglobulin G (IgG) responses beyond the first few weeks after symptom onset remain poorly understood.Methods
Within a large, well-phenotyped, diverse, prospective cohort of subjects with and without severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR)-confirmed infection and historical controls derived from cohorts with high prevalence of viral coinfections and samples taken during prior flu seasons, we measured SARS-CoV-2 serological responses (both IgG and IgM) using commercially available assays. We ca"],"journal":["Open forum infectious diseases"],"pubmed_title":["Dynamic Change and Clinical Relevance of Postinfectious SARS-CoV-2 Antibody Responses."],"pmcid":["PMC8083770"],"funding_grant_id":["20/COV/0305","666010"],"pubmed_authors":["Doran P","All Ireland Infectious Diseases Cohort Study Group","Gavin P","Lambert J","Leon AG","Feeney ER","Savinelli S","McNicholas B","Kelly C","McGettrick P","McGinty T","Bracken T","Inzitari R","Whelan B","Eustace J","DeBarra E","Kenny G","Yousif O","Tinago W","Sadlier C","Cottere AG","Green S","Courtney G","McCann K","Low J","Mallon PWG","Horgan M"],"additional_accession":[]},"is_claimable":false,"name":"Dynamic Change and Clinical Relevance of Postinfectious SARS-CoV-2 Antibody Responses.","description":"Background
Although reports suggest that most individuals with coronavirus disease 2019 (COVID-19) develop detectable antibodies postinfection, the kinetics, durability, and relative differences between immunoglobulin M (IgM) and immunoglobulin G (IgG) responses beyond the first few weeks after symptom onset remain poorly understood.Methods
Within a large, well-phenotyped, diverse, prospective cohort of subjects with and without severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR)-confirmed infection and historical controls derived from cohorts with high prevalence of viral coinfections and samples taken during prior flu seasons, we measured SARS-CoV-2 serological responses (both IgG and IgM) using commercially available assays. We ca","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-20T01:54:28.885Z","creation":"2022-02-11T05:50:14.463Z"},"accession":"S-EPMC8083770","cross_references":{"pubmed":["34377721"],"doi":["10.1093/ofid/ofab122"]}}