biostudies-literatureMallon PWGScience Foundation IrelandEuropean Union’s Horizon 2020 Research and Innovation Programmeofab122https://www.ebi.ac.uk/biostudies/studies/S-EPMC8083770biostudies-literatureUnknown8(8)<h4>Background</h4>Although reports suggest that most individuals with coronavirus disease 2019 (COVID-19) develop detectable antibodies postinfection, the kinetics, durability, and relative differences between immunoglobulin M (IgM) and immunoglobulin G (IgG) responses beyond the first few weeks after symptom onset remain poorly understood.<h4>Methods</h4>Within a large, well-phenotyped, diverse, prospective cohort of subjects with and without severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR)-confirmed infection and historical controls derived from cohorts with high prevalence of viral coinfections and samples taken during prior flu seasons, we measured SARS-CoV-2 serological responses (both IgG and IgM) using commercially available assays. We caOpen forum infectious diseasesDynamic Change and Clinical Relevance of Postinfectious SARS-CoV-2 Antibody Responses.PMC808377020/COV/0305666010Doran PAll Ireland Infectious Diseases Cohort Study GroupGavin PLambert JLeon AGFeeney ERSavinelli SMcNicholas BKelly CMcGettrick PMcGinty TBracken TInzitari RWhelan BEustace JDeBarra EKenny GYousif OTinago WSadlier CCottere AGGreen SCourtney GMcCann KLow JMallon PWGHorgan MfalseDynamic Change and Clinical Relevance of Postinfectious SARS-CoV-2 Antibody Responses.<h4>Background</h4>Although reports suggest that most individuals with coronavirus disease 2019 (COVID-19) develop detectable antibodies postinfection, the kinetics, durability, and relative differences between immunoglobulin M (IgM) and immunoglobulin G (IgG) responses beyond the first few weeks after symptom onset remain poorly understood.<h4>Methods</h4>Within a large, well-phenotyped, diverse, prospective cohort of subjects with and without severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR)-confirmed infection and historical controls derived from cohorts with high prevalence of viral coinfections and samples taken during prior flu seasons, we measured SARS-CoV-2 serological responses (both IgG and IgM) using commercially available assays. We ca2021-01-01T00:00:00Z2021 Aug2025-04-20T01:54:28.885Z2022-02-11T05:50:14.463ZS-EPMC80837703437772110.1093/ofid/ofab122