{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yuan X"],"funding":["NIDCR NIH HHS","U.S. Department of Health and Human Services","National Institute of Dental and Craniofacial Research","National Institutes of Health"],"pagination":["745-753"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8085107"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["48(5)"],"pubmed_abstract":["<h4>Aim</h4>To evaluate the similarities and differences in barrier function of a peri-implant epithelium (PIE) versus a native junctional epithelium (JE).<h4>Materials and methods</h4>A mouse model was used wherein titanium implants were placed sub-occlusally in healed extraction sites. The PIE was examined at multiple timepoints after implant placement, to capture and understand the temporal nature of its assembly and homeostatic status. Mitotic activity, hemidesmosomal attachment apparatus, and inflammatory responses in the PIE were compared against a JE. Additionally, we evaluated whether the PIE developed a Wnt-responsive stem cell niche like a JE.<h4>Results</h4>The PIE developed from oral epithelium (OE) that had, by the time of implant placement, lost all characteristics of a JE. C"],"journal":["Journal of clinical periodontology"],"pubmed_title":["Comparative analyses of the soft tissue interfaces around teeth and implants: Insights from a pre-clinical implant model."],"pmcid":["PMC8085107"],"funding_grant_id":["K99 DE028585","K99DE028585‐02"],"pubmed_authors":["Brunski JB","Chen J","Helms JA","Pei X","Yuan X","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"Comparative analyses of the soft tissue interfaces around teeth and implants: Insights from a pre-clinical implant model.","description":"<h4>Aim</h4>To evaluate the similarities and differences in barrier function of a peri-implant epithelium (PIE) versus a native junctional epithelium (JE).<h4>Materials and methods</h4>A mouse model was used wherein titanium implants were placed sub-occlusally in healed extraction sites. The PIE was examined at multiple timepoints after implant placement, to capture and understand the temporal nature of its assembly and homeostatic status. Mitotic activity, hemidesmosomal attachment apparatus, and inflammatory responses in the PIE were compared against a JE. Additionally, we evaluated whether the PIE developed a Wnt-responsive stem cell niche like a JE.<h4>Results</h4>The PIE developed from oral epithelium (OE) that had, by the time of implant placement, lost all characteristics of a JE. C","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2025-04-04T07:34:49.595Z","creation":"2025-04-04T07:34:49.595Z"},"accession":"S-EPMC8085107","cross_references":{"pubmed":["33713489"],"doi":["10.1111/jcpe.13446"]}}