{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bilska B"],"funding":["BLRD VA","NIAID NIH HHS","NIAMS NIH HHS"],"pagination":["1418-1427"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8085171"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(10)"],"pubmed_abstract":["Antimicrobial peptides (AMPs) are important components of the innate immune system and are involved in skin protection against environmental insults and in wound healing. Herein, we assessed the gene expression of chemerin (Rarres2), cathelicidin CRAMP (Camp), and three β-defensins (Defb1, Defb3, and Defb14) in mouse skin during light/dark cycle (LD 12:12) and constant darkness (DD). Next, we examined the survival of bacteria applied on the skin at specific times during the day. We found that the expression of Rarres2, Camp, and Defb1 was the highest at 4 h after the beginning of darkness, during high activity of mice. These rhythms, however, were not maintained under DD in the skin but were present in the liver. This indicated that in the case of skin, a circadian input was masked by dail"],"journal":["Experimental dermatology"],"pubmed_title":["Expression of antimicrobial peptide genes oscillates along day/night rhythm protecting mice skin from bacteria."],"pmcid":["PMC8085171"],"funding_grant_id":["R01 AR071189","R01 AR073004","R21 AI149267","I01 BX004293"],"pubmed_authors":["Pyza E","Kleszczynski K","Slominski AT","Cichy J","Bilska B","Zegar A"],"additional_accession":[]},"is_claimable":false,"name":"Expression of antimicrobial peptide genes oscillates along day/night rhythm protecting mice skin from bacteria.","description":"Antimicrobial peptides (AMPs) are important components of the innate immune system and are involved in skin protection against environmental insults and in wound healing. Herein, we assessed the gene expression of chemerin (Rarres2), cathelicidin CRAMP (Camp), and three β-defensins (Defb1, Defb3, and Defb14) in mouse skin during light/dark cycle (LD 12:12) and constant darkness (DD). Next, we examined the survival of bacteria applied on the skin at specific times during the day. We found that the expression of Rarres2, Camp, and Defb1 was the highest at 4 h after the beginning of darkness, during high activity of mice. These rhythms, however, were not maintained under DD in the skin but were present in the liver. This indicated that in the case of skin, a circadian input was masked by dail","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2025-04-19T04:24:43.639Z","creation":"2025-02-19T02:24:06.63Z"},"accession":"S-EPMC8085171","cross_references":{"pubmed":["33131146"],"doi":["10.1111/exd.14229"]}}