{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pandey K"],"funding":["National Institute of Allergy and Infectious Diseases","NIAID NIH HHS","NCI NIH HHS","NIH HHS"],"pagination":["1868-1885"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8085186"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["68(4)"],"pubmed_abstract":["Emerging and re-emerging viral diseases can create devastating effects on human lives and may also lead to economic crises. The ongoing COVID-19 pandemic due to the novel coronavirus (nCoV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan, China, has caused a global public health emergency. To date, the molecular mechanism of transmission of SARS-CoV-2, its clinical manifestations and pathogenesis is not completely understood. The global scientific community has intensified its efforts in understanding the biology of SARS-CoV-2 for development of vaccines and therapeutic interventions to prevent the rapid spread of the virus and to control mortality and morbidity associated with COVID-19. To understand the pathophysiology of SARS-CoV-2, appropriate animal models that mimic the biology of human SARS-CoV-2 infection are urgently needed. In this review, we outline animal models that have been used to study previous human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV). Importantly, we discuss models that are appropriate for SARS-CoV-2 as well as the advantages and disadvantages of various available methods."],"journal":["Transboundary and emerging diseases"],"pubmed_title":["Animal models for SARS-CoV-2 research: A comprehensive literature review."],"pmcid":["PMC8085186"],"funding_grant_id":["P30 CA036727","5P30 CA036727-33","R01 AI129745","P51 OD011133","5P30 CA036727‐33"],"pubmed_authors":["Acharya A","Mohan M","Reid SP","Pandey K","Ng CL","Byrareddy SN"],"additional_accession":[]},"is_claimable":false,"name":"Animal models for SARS-CoV-2 research: A comprehensive literature review.","description":"Emerging and re-emerging viral diseases can create devastating effects on human lives and may also lead to economic crises. The ongoing COVID-19 pandemic due to the novel coronavirus (nCoV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan, China, has caused a global public health emergency. To date, the molecular mechanism of transmission of SARS-CoV-2, its clinical manifestations and pathogenesis is not completely understood. The global scientific community has intensified its efforts in understanding the biology of SARS-CoV-2 for development of vaccines and therapeutic interventions to prevent the rapid spread of the virus and to control mortality and morbidity associated with COVID-19. To understand the pathophysiology of SARS-CoV-2, appropriate animal models that mimic the biology of human SARS-CoV-2 infection are urgently needed. In this review, we outline animal models that have been used to study previous human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV). Importantly, we discuss models that are appropriate for SARS-CoV-2 as well as the advantages and disadvantages of various available methods.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2024-12-04T06:10:18.076Z","creation":"2022-02-11T14:14:56.061Z"},"accession":"S-EPMC8085186","cross_references":{"pubmed":["33128861"],"doi":["10.1111/tbed.13907"]}}