{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stelmes JJ"],"funding":["Cancer Research UK"],"pagination":["81"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8088557"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Introduction
The current phase III EORTC 1420 Best-of trial (NCT02984410) compares the swallowing function after transoral surgery versus intensity modulated radiotherapy (RT) in patients with early-stage carcinoma of the oropharynx, supraglottis and hypopharynx. We report the analysis of the Benchmark Case (BC) procedures before patient recruitment with special attention to dysphagia/aspiration related structures (DARS).Materials and methods
Submitted RT volumes and plans from participating centers were analyzed and compared against the gold-standard expert delineations and dose distributions. Descriptive analysis of protocol deviations was conducted. Mean Sorensen-Dice similarity index (mDSI) and Hausdorff distance (mHD) were applied to evaluate the inter-observer variabi"],"journal":["Radiation oncology (London, England)"],"pubmed_title":["Quality assurance of radiotherapy in the ongoing EORTC 1420 \"Best of\" trial for early stage oropharyngeal, supraglottic and hypopharyngeal carcinoma: results of the benchmark case procedure."],"pmcid":["PMC8088557"],"funding_grant_id":["23714"],"pubmed_authors":["Stelmes JJ","Weber DC","Gregoire V","Branquinho A","Zimmermann F","Tomsej M","Fortpied C","Ozsahin M","Vu E","Kazmierska J","Andratschke N","Clementel E","Hurkmans EC","Vieillevigne L","Grant W","Simon C"],"additional_accession":[]},"is_claimable":false,"name":"Quality assurance of radiotherapy in the ongoing EORTC 1420 \"Best of\" trial for early stage oropharyngeal, supraglottic and hypopharyngeal carcinoma: results of the benchmark case procedure.","description":"Introduction
The current phase III EORTC 1420 Best-of trial (NCT02984410) compares the swallowing function after transoral surgery versus intensity modulated radiotherapy (RT) in patients with early-stage carcinoma of the oropharynx, supraglottis and hypopharynx. We report the analysis of the Benchmark Case (BC) procedures before patient recruitment with special attention to dysphagia/aspiration related structures (DARS).Materials and methods
Submitted RT volumes and plans from participating centers were analyzed and compared against the gold-standard expert delineations and dose distributions. Descriptive analysis of protocol deviations was conducted. Mean Sorensen-Dice similarity index (mDSI) and Hausdorff distance (mHD) were applied to evaluate the inter-observer variabi","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2026-05-08T21:29:09.819Z","creation":"2022-02-10T09:32:56.742Z"},"accession":"S-EPMC8088557","cross_references":{"pubmed":["33933118"],"doi":["10.1186/s13014-021-01809-2"]}}