biostudies-literatureStelmes JJCancer Research UK81https://www.ebi.ac.uk/biostudies/studies/S-EPMC8088557biostudies-literatureUnknown16(1)<h4>Introduction</h4>The current phase III EORTC 1420 Best-of trial (NCT02984410) compares the swallowing function after transoral surgery versus intensity modulated radiotherapy (RT) in patients with early-stage carcinoma of the oropharynx, supraglottis and hypopharynx. We report the analysis of the Benchmark Case (BC) procedures before patient recruitment with special attention to dysphagia/aspiration related structures (DARS).<h4>Materials and methods</h4>Submitted RT volumes and plans from participating centers were analyzed and compared against the gold-standard expert delineations and dose distributions. Descriptive analysis of protocol deviations was conducted. Mean Sorensen-Dice similarity index (mDSI) and Hausdorff distance (mHD) were applied to evaluate the inter-observer variabiRadiation oncology (London, England)Quality assurance of radiotherapy in the ongoing EORTC 1420 "Best of" trial for early stage oropharyngeal, supraglottic and hypopharyngeal carcinoma: results of the benchmark case procedure.PMC808855723714Stelmes JJWeber DCGregoire VBranquinho AZimmermann FTomsej MFortpied COzsahin MVu EKazmierska JAndratschke NClementel EHurkmans ECVieillevigne LGrant WSimon CfalseQuality assurance of radiotherapy in the ongoing EORTC 1420 "Best of" trial for early stage oropharyngeal, supraglottic and hypopharyngeal carcinoma: results of the benchmark case procedure.<h4>Introduction</h4>The current phase III EORTC 1420 Best-of trial (NCT02984410) compares the swallowing function after transoral surgery versus intensity modulated radiotherapy (RT) in patients with early-stage carcinoma of the oropharynx, supraglottis and hypopharynx. We report the analysis of the Benchmark Case (BC) procedures before patient recruitment with special attention to dysphagia/aspiration related structures (DARS).<h4>Materials and methods</h4>Submitted RT volumes and plans from participating centers were analyzed and compared against the gold-standard expert delineations and dose distributions. Descriptive analysis of protocol deviations was conducted. Mean Sorensen-Dice similarity index (mDSI) and Hausdorff distance (mHD) were applied to evaluate the inter-observer variabi2021-01-01T00:00:00Z2021 May2026-05-08T21:29:09.819Z2022-02-10T09:32:56.742ZS-EPMC80885573393311810.1186/s13014-021-01809-2