{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ward H"],"funding":["Medical Research Council","National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["100098"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8088780"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4"],"pubmed_abstract":["<h4>Background</h4>The time-concentrated nature of the first wave of the COVID-19 epidemic in England in March and April 2020 provides a natural experiment to measure changes in antibody positivity at the population level before onset of the second wave and initiation of the vaccination programme.<h4>Methods</h4>Three cross-sectional national surveys with non-overlapping random samples of the population in England undertaken between late June and September 2020 (REACT-2 study). 365,104 adults completed questionnaires and self-administered lateral flow immunoassay (LFIA) tests for IgG against SARS-CoV-2.<h4>Findings</h4>Overall, 17,576 people had detectable antibodies, a prevalence of 4.9% (95% confidence intervals 4.9, 5.0) when adjusted for test characteristics and weighted to the adult p"],"journal":["The Lancet regional health. Europe"],"pubmed_title":["Prevalence of antibody positivity to SARS-CoV-2 following the first peak of infection in England: Serial cross-sectional studies of 365,000 adults."],"pmcid":["PMC8088780"],"funding_grant_id":["200187/Z/15/Z","NF-SI-0617-10116","200861/Z/16/Z","MC_PC_20058","RP-2016-07-012","NF-SI-0617-10038","205456/Z/16/Z","MR/R015600/1"],"pubmed_authors":["Elliott J","Flower B","Ward H","Barclay W","Darzi A","Whitaker M","Elliott P","Ashby D","Daunt A","Ainslie K","Cooke GS","Riley S","Moshe M","Donnelly CA","Atchison C","Brown JC"],"additional_accession":[]},"is_claimable":false,"name":"Prevalence of antibody positivity to SARS-CoV-2 following the first peak of infection in England: Serial cross-sectional studies of 365,000 adults.","description":"<h4>Background</h4>The time-concentrated nature of the first wave of the COVID-19 epidemic in England in March and April 2020 provides a natural experiment to measure changes in antibody positivity at the population level before onset of the second wave and initiation of the vaccination programme.<h4>Methods</h4>Three cross-sectional national surveys with non-overlapping random samples of the population in England undertaken between late June and September 2020 (REACT-2 study). 365,104 adults completed questionnaires and self-administered lateral flow immunoassay (LFIA) tests for IgG against SARS-CoV-2.<h4>Findings</h4>Overall, 17,576 people had detectable antibodies, a prevalence of 4.9% (95% confidence intervals 4.9, 5.0) when adjusted for test characteristics and weighted to the adult p","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2025-04-21T19:35:47.632Z","creation":"2025-04-05T17:40:49.832Z"},"accession":"S-EPMC8088780","cross_references":{"pubmed":["33969335"],"doi":["10.1016/j.lanepe.2021.100098"]}}