{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Boer IH"],"funding":["NCATS NIH HHS","NHLBI","NIDDK NIH HHS","NCRR NIH HHS","NHLBI NIH HHS"],"pagination":["106318"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8089051"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["103"],"pubmed_abstract":["The INdividual response to VITamin D (INVITe) trial was a randomized, placebo-controlled, parallel group trial of vitamin D<sub>3</sub> supplementation (2000 IU daily) designed to determine clinical and genetic characteristics that modify the response to vitamin D supplementation. To enhance internal and external validity and reduce cost, the INVITe trial was nested within the Multi-Ethnic Study of Atherosclerosis (MESA), an ongoing prospective observational cohort study. The INVITe trial enrolled a community-based population of 666 racially and ethnically diverse participants from January 2017 to April 2019. This represents 30% of 2210 MESA participants approached for screening, and 96% of those found to be eligible. Barriers to enrollment included delayed initiation of the trial relative"],"journal":["Contemporary clinical trials"],"pubmed_title":["The Multi-Ethnic Study of Atherosclerosis individual response to vitamin D trial: Building a randomized clinical trial into an observational cohort study."],"pmcid":["PMC8089051"],"funding_grant_id":["UL1 TR001420","UL1 TR001881","R01 HL071205","UL1 RR033176","N01HC95159","75N92020D00007","UL1 RR025005","75N92020D00001","75N92020D00002","T32 DK007467","P30 DK035816","75N92020D00005","75N92020D00006","75N92020D00003","75N92020D00004","UL1 TR000040","R01 HL096875","HHSN268201500003C","R01 HL071259","N01HC95160","R01 HL071258","UL1 TR001079","N01HC95161","N01HC95162","N01HC95163","P30 DK017047","N01HC95164","N01HC95165","R01 HL071051","N01HC95166","R01 HL071251","N01HC95167","N01HC95168","R01 HL071250","N01HC95169","R01 HL071252","R01 DK088762","R01 DK099199","HHSN268201500003I"],"pubmed_authors":["Watson KE","Psaty BM","Hoofnagle AN","Rotter JI","Rice KM","Williams K","Siscovick DS","Liu KJ","Burke GL","Allen NB","Hsu S","Li X","Prince DK","de Boer IH","Michos ED","Tracy RP","Kestenbaum BR","McClelland RL","Shea SJ"],"additional_accession":[]},"is_claimable":false,"name":"The Multi-Ethnic Study of Atherosclerosis individual response to vitamin D trial: Building a randomized clinical trial into an observational cohort study.","description":"The INdividual response to VITamin D (INVITe) trial was a randomized, placebo-controlled, parallel group trial of vitamin D<sub>3</sub> supplementation (2000 IU daily) designed to determine clinical and genetic characteristics that modify the response to vitamin D supplementation. To enhance internal and external validity and reduce cost, the INVITe trial was nested within the Multi-Ethnic Study of Atherosclerosis (MESA), an ongoing prospective observational cohort study. The INVITe trial enrolled a community-based population of 666 racially and ethnically diverse participants from January 2017 to April 2019. This represents 30% of 2210 MESA participants approached for screening, and 96% of those found to be eligible. Barriers to enrollment included delayed initiation of the trial relative","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-04T23:02:24.135Z","creation":"2025-04-04T23:02:24.135Z"},"accession":"S-EPMC8089051","cross_references":{"pubmed":["33588078"],"doi":["10.1016/j.cct.2021.106318"]}}