{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee JK"],"funding":["Intellectual and Developmental Disabilities Research Center","NICHD NIH HHS","NIMH NIH HHS","National Institute of Mental Health","National Institute of Child Health and Human Development"],"pagination":["286-294"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8089123"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["90(5)"],"pubmed_abstract":["Background
Cerebral overgrowth is frequently reported in children but not in adults with autism spectrum disorder (ASD). This suggests that early cerebral overgrowth is followed by normalization of cerebral volumes. However, this notion is predicated on cross-sectional research that is vulnerable to sampling bias. For example, autistic individuals with disproportionate megalencephaly, a subgroup with higher rates of intellectual disability and larger cerebral volumes, may be underrepresented in studies of adolescents and adults. Furthermore, extant studies have cohorts that are predominately male, thus limiting knowledge of cerebral growth in females with ASD.Methods
Growth of total cerebral volume, gray matter (GM) volume, and white matter volume as well as proportion of G"],"journal":["Biological psychiatry"],"pubmed_title":["Longitudinal Evaluation of Cerebral Growth Across Childhood in Boys and Girls With Autism Spectrum Disorder."],"pmcid":["PMC8089123"],"funding_grant_id":["P50 HD103526","R01 MH104438","R01 MH106518","P50 HD093079","R01 MH103371","R01 MH103284","T32 MH073124","U54 HD079125"],"pubmed_authors":["Nordahl CW","Rogers S","Amaral DG","Lee JK","Ozonoff S","Solomon M","Andrews DS"],"additional_accession":[]},"is_claimable":false,"name":"Longitudinal Evaluation of Cerebral Growth Across Childhood in Boys and Girls With Autism Spectrum Disorder.","description":"Background
Cerebral overgrowth is frequently reported in children but not in adults with autism spectrum disorder (ASD). This suggests that early cerebral overgrowth is followed by normalization of cerebral volumes. However, this notion is predicated on cross-sectional research that is vulnerable to sampling bias. For example, autistic individuals with disproportionate megalencephaly, a subgroup with higher rates of intellectual disability and larger cerebral volumes, may be underrepresented in studies of adolescents and adults. Furthermore, extant studies have cohorts that are predominately male, thus limiting knowledge of cerebral growth in females with ASD.Methods
Growth of total cerebral volume, gray matter (GM) volume, and white matter volume as well as proportion of G","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-27T00:14:26.112Z","creation":"2025-04-06T17:47:47.409Z"},"accession":"S-EPMC8089123","cross_references":{"pubmed":["33388135"],"doi":["10.1016/j.biopsych.2020.10.014"]}}