biostudies-literatureTeran-Navarro HInstituto de Investigación Marqués de ValdecillaInstituto de Salud Carlos IIIMinisterio de Ciencia, Innovación y Universidades632304https://www.ebi.ac.uk/biostudies/studies/S-EPMC8092121biostudies-literatureUnknown12Cross-reactive vaccines recognize common molecular patterns in pathogens and are able to confer broad spectrum protection against different infections. Antigens common to pathogenic bacteria that induce broad immune responses, such as the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of the genera <i>Listeria, Mycobacterium</i>, or <i>Streptococcus</i>, whose sequences present more than 95% homology at the N-terminal GAPDH_1-22 peptide, are putative candidates for universal vaccines. Here, we explore vaccine formulations based on dendritic cells (DC) loaded with two molecular forms of <i>Listeria monocytogenes</i> GAPDH (LM-GAPDH), such as mRNA carriers or recombinant proteins, and compare them with the same molecular forms of three other antigens used in experimental vaccinesFrontiers in immunologyA Comparison Between Recombinant <i>Listeria</i> GAPDH Proteins and GAPDH Encoding mRNA Conjugated to Lipids as Cross-Reactive Vaccines for <i>Listeria, Mycobacterium</i>, and <i>Streptococcus</i>.PMC8092121SAF2012-34203PI19-01580DTS18-00022INNVAL19/26CIB16-NM009Salcines-Cuevas DFresno MPerez-Del Molino Bernal ICCalvo-Montes JAlvarez-Dominguez CTeran-Navarro HCalderon-Gonzalez RYanez-Diaz STobes RfalseA Comparison Between Recombinant <i>Listeria</i> GAPDH Proteins and GAPDH Encoding mRNA Conjugated to Lipids as Cross-Reactive Vaccines for <i>Listeria, Mycobacterium</i>, and <i>Streptococcus</i>.Cross-reactive vaccines recognize common molecular patterns in pathogens and are able to confer broad spectrum protection against different infections. Antigens common to pathogenic bacteria that induce broad immune responses, such as the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of the genera <i>Listeria, Mycobacterium</i>, or <i>Streptococcus</i>, whose sequences present more than 95% homology at the N-terminal GAPDH_1-22 peptide, are putative candidates for universal vaccines. Here, we explore vaccine formulations based on dendritic cells (DC) loaded with two molecular forms of <i>Listeria monocytogenes</i> GAPDH (LM-GAPDH), such as mRNA carriers or recombinant proteins, and compare them with the same molecular forms of three other antigens used in experimental vaccines2021-01-01T00:00:00Z20212026-04-07T15:03:07.92Z2022-02-10T09:43:24.925ZS-EPMC80921213395370910.3389/fimmu.2021.632304