{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nadarajan S"],"funding":["HHS | NIH | National Institute of General Medical Sciences"],"pagination":["e2016363118"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8092412"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["118(17)"],"pubmed_abstract":["The position of recombination events established along chromosomes in early prophase I and the chromosome remodeling that takes place in late prophase I are intrinsically linked steps of meiosis that need to be tightly regulated to ensure accurate chromosome segregation and haploid gamete formation. Here, we show that RAD-51 foci, which form at the sites of programmed meiotic DNA double-strand breaks (DSBs), exhibit a biased distribution toward off-centered positions along the chromosomes in wild-type Caenorhabditis elegans, and we identify two meiotic roles for chromatin-associated protein HIM-17 that ensure normal chromosome remodeling in late prophase I. During early prophase I, HIM-17 regulates the distribution of DSB-dependent RAD-51 foci and crossovers on chromosomes, which is critic"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["HIM-17 regulates the position of recombination events and GSP-1/2 localization to establish short arm identity on bivalents in meiosis."],"pmcid":["PMC8092412"],"funding_grant_id":["R01GM072551"],"pubmed_authors":["Nadarajan S","Altendorfer E","Saito TT","Colaiacovo MP","Martinez-Garcia M"],"additional_accession":[]},"is_claimable":false,"name":"HIM-17 regulates the position of recombination events and GSP-1/2 localization to establish short arm identity on bivalents in meiosis.","description":"The position of recombination events established along chromosomes in early prophase I and the chromosome remodeling that takes place in late prophase I are intrinsically linked steps of meiosis that need to be tightly regulated to ensure accurate chromosome segregation and haploid gamete formation. Here, we show that RAD-51 foci, which form at the sites of programmed meiotic DNA double-strand breaks (DSBs), exhibit a biased distribution toward off-centered positions along the chromosomes in wild-type Caenorhabditis elegans, and we identify two meiotic roles for chromatin-associated protein HIM-17 that ensure normal chromosome remodeling in late prophase I. During early prophase I, HIM-17 regulates the distribution of DSB-dependent RAD-51 foci and crossovers on chromosomes, which is critic","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-26T23:38:46.61Z","creation":"2025-04-06T17:38:46.236Z"},"accession":"S-EPMC8092412","cross_references":{"pubmed":["33883277"],"doi":["10.1073/pnas.2016363118"]}}