{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Johnson WL"],"funding":["National Institute of Allergy and Infectious Diseases","National Eye Institute","Research to Prevent Blindness","NIAID NIH HHS","School of Medicine and Dentistry, University of Rochester"],"pagination":["e0250975"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8092774"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(5)"],"pubmed_abstract":["Staphylococcus aureus is a major cause of ocular infections, often resulting in devastating vision loss. Despite the significant morbidity associated with these infections, little is yet known regarding the specific strain types that may have a predilection for ocular tissues nor the set of virulence factors that drive its pathogenicity in this specific biological niche. Whole genome sequencing (WGS) can provide valuable insight in this regard by providing a prospective, comprehensive assessment of the strain types and virulence factors driving disease among specific subsets of clinical isolates. As such, a set of 163-member S. aureus ocular clinical strains were sequenced and assessed for both common strain types (multilocus sequence type (MLST), spa, agr) associated with ocular infection"],"journal":["PloS one"],"pubmed_title":["Genomics of Staphylococcus aureus ocular isolates."],"pmcid":["PMC8092774"],"funding_grant_id":["Career Development Award 2020","K08 EYE29012","Unrestricted Departmental Grant","Departmental Grant - Pathology and Laboratory Medicine","R01 AI134685","AI134685"],"pubmed_authors":["Johnson WL","Sohn MB","Wozniak RAF","Chatterjee P","Pecora N","Dunman PM","Taffner S"],"additional_accession":[]},"is_claimable":false,"name":"Genomics of Staphylococcus aureus ocular isolates.","description":"Staphylococcus aureus is a major cause of ocular infections, often resulting in devastating vision loss. Despite the significant morbidity associated with these infections, little is yet known regarding the specific strain types that may have a predilection for ocular tissues nor the set of virulence factors that drive its pathogenicity in this specific biological niche. Whole genome sequencing (WGS) can provide valuable insight in this regard by providing a prospective, comprehensive assessment of the strain types and virulence factors driving disease among specific subsets of clinical isolates. As such, a set of 163-member S. aureus ocular clinical strains were sequenced and assessed for both common strain types (multilocus sequence type (MLST), spa, agr) associated with ocular infection","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-04-30T00:20:06.721Z","creation":"2025-02-19T04:51:37.43Z"},"accession":"S-EPMC8092774","cross_references":{"pubmed":["33939761"],"doi":["10.1371/journal.pone.0250975"]}}