{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Badjatia N"],"funding":["NIA NIH HHS","NIDDK NIH HHS","RRD VA","NINDS NIH HHS"],"pagination":["46-55"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8093316"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(1)"],"pubmed_abstract":["<h4>Introduction</h4>Aneurysmal subarachnoid hemorrhage (SAH) survivors live with long-term residual physical and cognitive disability. We studied whether neuromuscular electrical stimulation (NMES) and high-protein supplementation (HPRO) in the first 2 weeks after SAH could preserve neuromotor and cognitive function as compared to standard of care (SOC) for nutrition and mobilization.<h4>Methods</h4>SAH subjects with a Hunt Hess (HH) grade > 1,modified Fisher score > 1 and BMI < 40 kg/m<sup>2</sup> were randomly assigned to SOC or NMES + HPRO. NMES was delivered to bilateral quadricep muscles daily during two 30-min sessions along with HPRO (goal:1.8 g/kg/day) between post-bleed day (PBD) 0 and 14. Primary endpoint was atrophy in the quadricep muscle as measured by the percentage differen"],"journal":["Neurocritical care"],"pubmed_title":["Neuromuscular Electrical Stimulation and High-Protein Supplementation After Subarachnoid Hemorrhage: A Single-Center Phase 2 Randomized Clinical Trial."],"pmcid":["PMC8093316"],"funding_grant_id":["I01 RX000550","P30 DK072488","R01 NS105503","IK6 RX003977","P30 AG028747"],"pubmed_authors":["Sanchez S","Simard JM","Motta M","Chang W","Parikh G","Wittenberg GF","Judd G","Morris N","Sorkin J","Hausladen R","Hering D","Ryan AS","Badjatia N"],"additional_accession":[]},"is_claimable":false,"name":"Neuromuscular Electrical Stimulation and High-Protein Supplementation After Subarachnoid Hemorrhage: A Single-Center Phase 2 Randomized Clinical Trial.","description":"<h4>Introduction</h4>Aneurysmal subarachnoid hemorrhage (SAH) survivors live with long-term residual physical and cognitive disability. We studied whether neuromuscular electrical stimulation (NMES) and high-protein supplementation (HPRO) in the first 2 weeks after SAH could preserve neuromotor and cognitive function as compared to standard of care (SOC) for nutrition and mobilization.<h4>Methods</h4>SAH subjects with a Hunt Hess (HH) grade > 1,modified Fisher score > 1 and BMI < 40 kg/m<sup>2</sup> were randomly assigned to SOC or NMES + HPRO. NMES was delivered to bilateral quadricep muscles daily during two 30-min sessions along with HPRO (goal:1.8 g/kg/day) between post-bleed day (PBD) 0 and 14. Primary endpoint was atrophy in the quadricep muscle as measured by the percentage differen","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2026-05-08T02:01:30.709Z","creation":"2025-04-04T08:13:40.877Z"},"accession":"S-EPMC8093316","cross_references":{"pubmed":["33150572"],"doi":["10.1007/s12028-020-01138-4"]}}