biostudies-literatureBadjatia NNIA NIH HHSNIDDK NIH HHSRRD VANINDS NIH HHS46-55https://www.ebi.ac.uk/biostudies/studies/S-EPMC8093316biostudies-literatureUnknown35(1)<h4>Introduction</h4>Aneurysmal subarachnoid hemorrhage (SAH) survivors live with long-term residual physical and cognitive disability. We studied whether neuromuscular electrical stimulation (NMES) and high-protein supplementation (HPRO) in the first 2 weeks after SAH could preserve neuromotor and cognitive function as compared to standard of care (SOC) for nutrition and mobilization.<h4>Methods</h4>SAH subjects with a Hunt Hess (HH) grade > 1,modified Fisher score > 1 and BMI < 40 kg/m² were randomly assigned to SOC or NMES + HPRO. NMES was delivered to bilateral quadricep muscles daily during two 30-min sessions along with HPRO (goal:1.8 g/kg/day) between post-bleed day (PBD) 0 and 14. Primary endpoint was atrophy in the quadricep muscle as measured by the percentage differenNeurocritical careNeuromuscular Electrical Stimulation and High-Protein Supplementation After Subarachnoid Hemorrhage: A Single-Center Phase 2 Randomized Clinical Trial.PMC8093316I01 RX000550P30 DK072488R01 NS105503IK6 RX003977P30 AG028747Sanchez SSimard JMMotta MChang WParikh GWittenberg GFJudd GMorris NSorkin JHausladen RHering DRyan ASBadjatia NfalseNeuromuscular Electrical Stimulation and High-Protein Supplementation After Subarachnoid Hemorrhage: A Single-Center Phase 2 Randomized Clinical Trial.<h4>Introduction</h4>Aneurysmal subarachnoid hemorrhage (SAH) survivors live with long-term residual physical and cognitive disability. We studied whether neuromuscular electrical stimulation (NMES) and high-protein supplementation (HPRO) in the first 2 weeks after SAH could preserve neuromotor and cognitive function as compared to standard of care (SOC) for nutrition and mobilization.<h4>Methods</h4>SAH subjects with a Hunt Hess (HH) grade > 1,modified Fisher score > 1 and BMI < 40 kg/m² were randomly assigned to SOC or NMES + HPRO. NMES was delivered to bilateral quadricep muscles daily during two 30-min sessions along with HPRO (goal:1.8 g/kg/day) between post-bleed day (PBD) 0 and 14. Primary endpoint was atrophy in the quadricep muscle as measured by the percentage differen2021-01-01T00:00:00Z2021 Aug2026-05-08T02:01:30.709Z2025-04-04T08:13:40.877ZS-EPMC80933163315057210.1007/s12028-020-01138-4