biostudies-literatureWang XNational Institute of Environmental Health SciencesNIA NIH HHSNCRR NIH HHSNational Institute of Nursing ResearchNIEHS NIH HHSNHLBI NIH HHSNational Heart, Lung, and Blood InstituteNational Institute on AgingNIDDK NIH HHSACL HHSNational Institute for Occupational Safety and HealthNIOSH CDC HHSNINR NIH HHS110426https://www.ebi.ac.uk/biostudies/studies/S-EPMC8093324biostudies-literatureUnknown196<h4>Background</h4>Information on the associations between metal exposures and adipokines in human populations is limited and results are inconsistent. We evaluated the associations between metals and adipokines.<h4>Methods</h4>Urinary concentrations of 15 metals (arsenic, barium, cadmium, cobalt, cesium, copper, mercury, manganese, molybdenum, nickel, lead, antimony, tin, thallium, and zinc) were measured in 1999-2000 among 1228 women of the Study of Women's Health Across the Nation Multi-Pollutant Study. Serum adipokines including high molecular weight (HMW)-adiponectin, leptin, and soluble leptin receptor (sOB-R) were measured at the follow-up visit (2002-2003). Linear regression models with adaptive elastic-net (AENET) were fit to identify metals associated with adipokines and to compuEnvironmental researchUrinary metals and adipokines in midlife women: The Study of Women's Health Across the nation (SWAN).PMC8093324U01 AG012554R01 ES026578U01 AG012553U01 AG012531P30 DK092926R01 ES026964U01 AG012535U01 AG012546U01 AG012539T42 OH008455U01 AG012505R21 HL091290U01 AG017719P30 ES017885P30 DK020572U19 AG063720U01 AG012495U01 NR004061UL1 RR024131T42OH008455Karvonen-Gutierrez CAMukherjee BHerman WHWang XPark SKfalseUrinary metals and adipokines in midlife women: The Study of Women's Health Across the nation (SWAN).<h4>Background</h4>Information on the associations between metal exposures and adipokines in human populations is limited and results are inconsistent. We evaluated the associations between metals and adipokines.<h4>Methods</h4>Urinary concentrations of 15 metals (arsenic, barium, cadmium, cobalt, cesium, copper, mercury, manganese, molybdenum, nickel, lead, antimony, tin, thallium, and zinc) were measured in 1999-2000 among 1228 women of the Study of Women's Health Across the Nation Multi-Pollutant Study. Serum adipokines including high molecular weight (HMW)-adiponectin, leptin, and soluble leptin receptor (sOB-R) were measured at the follow-up visit (2002-2003). Linear regression models with adaptive elastic-net (AENET) were fit to identify metals associated with adipokines and to compu2021-01-01T00:00:00Z2021 May2025-04-04T10:15:51.444Z2025-04-04T10:15:51.444ZS-EPMC80933243315710610.1016/j.envres.2020.110426