{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Almekhlafi MA"],"funding":["Medical Research Council"],"pagination":["709-717"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8094030"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["78(6)"],"pubmed_abstract":["<h4>Importance</h4>The benefits of endovascular thrombectomy (EVT) are time dependent. Prior studies may have underestimated the time-benefit association because time of onset is imprecisely known.<h4>Objective</h4>To assess the lifetime outcomes associated with speed of endovascular thrombectomy in patients with acute ischemic stroke due to large-vessel occlusion (LVO).<h4>Data sources</h4>PubMed was searched for randomized clinical trials of stent retriever thrombectomy devices vs medical therapy in patients with anterior circulation LVO within 12 hours of last known well time, and for which a peer-reviewed, complete primary results article was published by August 1, 2020.<h4>Study selection</h4>All randomized clinical trials of stent retriever thrombectomy devices vs medical therapy in "],"journal":["JAMA neurology"],"pubmed_title":["Healthy Life-Year Costs of Treatment Speed From Arrival to Endovascular Thrombectomy in Patients With Ischemic Stroke: A Meta-analysis of Individual Patient Data From 7 Randomized Clinical Trials."],"pmcid":["PMC8094030"],"funding_grant_id":["MR/N003403/1"],"pubmed_authors":["Kappelle LJ","Williams D","Koudstaal PJ","Coutts SB","Siddiqui AH","Nederkoorn PJ","van Dijk LC","Wu TY","Badve M","Muir KW","Donnan GA","Brouwer PA","Thornton J","Linares G","Davalos A","Aerden LAM","de Miquel MA","Pereira VM","Tampieri D","Smith EE","Mitchell PJ","Eesa M","Rubiera M","Levy EI","Beenen LFM","Desmond PM","Shankar J","White P","Jenniskens SFM","van Rooij WJJ","Roy D","Brown MM","van Zwam WH","Kelly M","Dixit A","Levi CR","Vroomen PC","van Hasselt BAAM","Emmer BJ","de Bruijn SF","Sajobi TT","Baxter BW","Jovin TG","Mitha AP","Shuaib A","Blasco J","Flach HZ","van Oostayen JA","Saver JL","Visser MC","Churilov L","Murray A","de Kort PLM","Dowling RJ","van den Berg LA","Oppenheim C","Montanera WJ","Aja L","Castano C","Dorado L","Harrington TJ","Ang T","den Hertog HM","San Roman L","Staals J","Hofmeijer J","Simpson MA","Quesada H","Chandra RV","Choe H","Millan M","Ducrocq X","Dewey HM","Majoie CBLM","Eshghi O","van der Lugt A","Steinfort BS","van Walderveen MAA","Phan TG","Messow CM","Almekhlafi MA","Wong JH","Lenthall R","Lowerison MW","de Vries J","Ford GA","Wardlaw J","van den Berg R","Beumer D","Clifton A","Robertson F","Ma H","Holmstedt CA","Devlin TG","Jankowitz B","Rice H","Karas GB","Bot JCJ","Soudant M","Mattle HP","du Mesnil de Rochemont R","Poppe AY","Reddy VK","Bonafe A","Cobo E","Mandzia JL","Wijeratne T","Singer OC","Parsons MW","van den Berg-Vos RM","McGuinness B","Moulin T","Rovira A","Frei DF","Bladin CF","de Villiers L","Chong W","Mas JL","Hernandez-Perez M","Burns PA","Kamal NR","Swartz RH","van Dijk EJ","Miteff F","Boiten J","Vos JA","Rempel JL","Molina CA","Willinsky RA","Cognard C","Sohn SI","Priglinger M","Schonewille WJ","Silver FL","Davis SM","Roos YBWEM","Cardona P","Steyerberg EW","Nogueira RG","Fransen PSS","Urra X","Jahan R","Mitchell P","Tielbeek AV","Chamorro A","Albers GW","Jansen O","Kleinig TJ","Cohen DJ","Sprengers MES","van den Berg JSP","Ford I","Sapkota BL","Campbell BCV","Schreuder THCML","Faulder KC","Hacke W","HERMES Trialists Collaboration","Goyal M","Berkhemer OA","Yoo AJ","Freeman J","Lingsma HF","Keizer K","Lopes DK","Hill MD","Menon BK","Brooks M","Bang OY","Tomasello A","Barber PA","Lo RH","Wermer MJH","Heo JH","Abilleira S","Madigan J","von Kummer R","Dowlatshahi D","Demchuk AM","Oxley TJ","van Oostenbrugge RJ","Weill A","Marquering HA","Dallinga RJ","Krause M","Yassi N","Diener HC","Bracard S","Gerrits DG","Gallofre M","Subramaniam S","Cloud GC","Serena J","Scroop R","Lycklama A Nijeholt GJ","Yavagal DR","Dippel DWJ","Lopez-Cancio E","Ryckborst KJ","Ribo M","Morrish WF","Guillemin F","Heijboer RJJ","Yan B","Brown S"],"additional_accession":[]},"is_claimable":false,"name":"Healthy Life-Year Costs of Treatment Speed From Arrival to Endovascular Thrombectomy in Patients With Ischemic Stroke: A Meta-analysis of Individual Patient Data From 7 Randomized Clinical Trials.","description":"<h4>Importance</h4>The benefits of endovascular thrombectomy (EVT) are time dependent. Prior studies may have underestimated the time-benefit association because time of onset is imprecisely known.<h4>Objective</h4>To assess the lifetime outcomes associated with speed of endovascular thrombectomy in patients with acute ischemic stroke due to large-vessel occlusion (LVO).<h4>Data sources</h4>PubMed was searched for randomized clinical trials of stent retriever thrombectomy devices vs medical therapy in patients with anterior circulation LVO within 12 hours of last known well time, and for which a peer-reviewed, complete primary results article was published by August 1, 2020.<h4>Study selection</h4>All randomized clinical trials of stent retriever thrombectomy devices vs medical therapy in ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-04T10:16:10.217Z","creation":"2025-04-04T10:16:10.217Z"},"accession":"S-EPMC8094030","cross_references":{"pubmed":["33938914"],"doi":["10.1001/jamaneurol.2021.1055"]}}