{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(3)"],"submitter":["Barski D"],"pubmed_abstract":["The gene for the tissue inhibitor of metalloproteinase 3 (TIMP3) on 22q12.3 had been reported to be inactivated by promoter methylation in various types of cancers, with controversial findings in meningiomas. We performed direct sodium bisulfite sequencing in a series of 50 meningiomas, including 27 benign meningiomas [World Health Organization (WHO) grade I], 11 atypical meningiomas (WHO grade II) and 12 anaplastic meningiomas (WHO grade III), and found hypermethylation of TIMP3 in 67% of anaplastic meningiomas, but only 22% of atypical and 17% of benign meningiomas. Moreover, TIMP3 methylation scores were significantly inversely correlated with TIMP3 mRNA expression levels (P = 0.0123), and treatment of the meningioma cell line Ben-Men-1 with demethylating agents induced an increased TIM"],"journal":["Brain pathology (Zurich, Switzerland)"],"pagination":["623-31"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8094659"],"repository":["biostudies-literature"],"pubmed_title":["Hypermethylation and transcriptional downregulation of the TIMP3 gene is associated with allelic loss on 22q12.3 and malignancy in meningiomas."],"pmcid":["PMC8094659"],"pubmed_authors":["Reifenberger G","Barski D","Riemenschneider MJ","Wolter M"],"additional_accession":[]},"is_claimable":false,"name":"Hypermethylation and transcriptional downregulation of the TIMP3 gene is associated with allelic loss on 22q12.3 and malignancy in meningiomas.","description":"The gene for the tissue inhibitor of metalloproteinase 3 (TIMP3) on 22q12.3 had been reported to be inactivated by promoter methylation in various types of cancers, with controversial findings in meningiomas. We performed direct sodium bisulfite sequencing in a series of 50 meningiomas, including 27 benign meningiomas [World Health Organization (WHO) grade I], 11 atypical meningiomas (WHO grade II) and 12 anaplastic meningiomas (WHO grade III), and found hypermethylation of TIMP3 in 67% of anaplastic meningiomas, but only 22% of atypical and 17% of benign meningiomas. Moreover, TIMP3 methylation scores were significantly inversely correlated with TIMP3 mRNA expression levels (P = 0.0123), and treatment of the meningioma cell line Ben-Men-1 with demethylating agents induced an increased TIM","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 May","modification":"2026-05-09T11:40:25.109Z","creation":"2022-02-11T10:11:21.058Z"},"accession":"S-EPMC8094659","cross_references":{"pubmed":["19922547"],"doi":["10.1111/j.1750-3639.2009.00340.x"]}}