biostudies-literatureUnknown16(5)Nerlich AGIn paleopathology, morphological and molecular evidence for infection by mycobacteria of the M. tuberculosis complex (MTC) is frequently associated with early death. In the present report, we describe a multidisciplinary study of a well-preserved mummy from Napoleonic times with a long-standing tuberculous infection by M. tuberculosis senso stricto who died at the age of 88 years of focal and non-MTB related bronchopneumonia. The well-preserved natural mummy of the Royal Bavarian General, Count Heinrich LII Reuss-Köstritz (1763-1851 CE), was extensively investigated by macro- and histomorphology, whole body CT scans and organ radiography, various molecular tissue analyses, including stable isotope analysis and molecular genetic tests. We identified signs for a long-standing, but terminallyPloS onee0249955https://www.ebi.ac.uk/biostudies/studies/S-EPMC8096010biostudies-literatureChronic active non-lethal human-type tuberculosis in a high royal Bavarian officer of Napoleonic times-a mummy study.PMC8096010Lehn CBayer BRocker PKirchhoff SMBachmeier BEPanzer SPeschel OKNerlich AGAnslinger KfalseChronic active non-lethal human-type tuberculosis in a high royal Bavarian officer of Napoleonic times-a mummy study.In paleopathology, morphological and molecular evidence for infection by mycobacteria of the M. tuberculosis complex (MTC) is frequently associated with early death. In the present report, we describe a multidisciplinary study of a well-preserved mummy from Napoleonic times with a long-standing tuberculous infection by M. tuberculosis senso stricto who died at the age of 88 years of focal and non-MTB related bronchopneumonia. The well-preserved natural mummy of the Royal Bavarian General, Count Heinrich LII Reuss-Köstritz (1763-1851 CE), was extensively investigated by macro- and histomorphology, whole body CT scans and organ radiography, various molecular tissue analyses, including stable isotope analysis and molecular genetic tests. We identified signs for a long-standing, but terminally2021-01-01T00:00:00Z20212026-05-08T02:48:31.254Z2022-02-10T10:27:52.103ZS-EPMC80960103394553610.1371/journal.pone.0249955