{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Keegan RM"],"funding":["National Institute of Neurological Disorders and Stroke","NIA NIH HHS","NINDS NIH HHS","NCI NIH HHS","National Institutes of Health","NIGMS NIH HHS","National Institute on Aging"],"pagination":["e1009535"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8096092"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(4)"],"pubmed_abstract":["It has become increasingly clear that retrotransposons (RTEs) are more widely expressed in somatic tissues than previously appreciated. RTE expression has been implicated in a myriad of biological processes ranging from normal development and aging, to age related diseases such as cancer and neurodegeneration. Long Terminal Repeat (LTR)-RTEs are evolutionary ancestors to, and share many features with, exogenous retroviruses. In fact, many organisms contain endogenous retroviruses (ERVs) derived from exogenous retroviruses that integrated into the germ line. These ERVs are inherited in Mendelian fashion like RTEs, and some retain the ability to transmit between cells like viruses, while others develop the ability to act as RTEs. The process of evolutionary transition between LTR-RTE and ret"],"journal":["PLoS genetics"],"pubmed_title":["Intercellular viral spread and intracellular transposition of Drosophila gypsy."],"pmcid":["PMC8096092"],"funding_grant_id":["T32 GM008444","5R01NS091748","K22 CA226047","1RF1AG057338","R01 NS091748","RF1 AG057338"],"pubmed_authors":["Chang YH","Dubnau J","Keegan RM","Metzger MJ","Talbot LR"],"additional_accession":[]},"is_claimable":false,"name":"Intercellular viral spread and intracellular transposition of Drosophila gypsy.","description":"It has become increasingly clear that retrotransposons (RTEs) are more widely expressed in somatic tissues than previously appreciated. RTE expression has been implicated in a myriad of biological processes ranging from normal development and aging, to age related diseases such as cancer and neurodegeneration. Long Terminal Repeat (LTR)-RTEs are evolutionary ancestors to, and share many features with, exogenous retroviruses. In fact, many organisms contain endogenous retroviruses (ERVs) derived from exogenous retroviruses that integrated into the germ line. These ERVs are inherited in Mendelian fashion like RTEs, and some retain the ability to transmit between cells like viruses, while others develop the ability to act as RTEs. The process of evolutionary transition between LTR-RTE and ret","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-19T02:58:35.81Z","creation":"2025-04-19T02:58:35.81Z"},"accession":"S-EPMC8096092","cross_references":{"pubmed":["33886543"],"doi":["10.1371/journal.pgen.1009535"]}}