biostudies-literatureSan Miguel YNational Cancer InstituteNCI NIH HHSNational Institutes of HealthHSRD VA1997-2005.e3https://www.ebi.ac.uk/biostudies/studies/S-EPMC8096663biostudies-literatureUnknown160(6)<h4>Background and aims</h4>The optimal time interval for diagnostic colonoscopy completion after an abnormal stool-based colorectal cancer (CRC) screening test is uncertain. We examined the association between time to colonoscopy and CRC outcomes among individuals who underwent diagnostic colonoscopy after abnormal stool-based screening.<h4>Methods</h4>We performed a retrospective cohort study of veterans age 50 to 75 years with an abnormal fecal occult blood test (FOBT) or fecal immunochemical test (FIT) between 1999 and 2010. We used multivariable Cox proportional hazards to generate CRC-specific incidence and mortality hazard ratios (HRs) and 95% confidence intervals (CI) for 3-month colonoscopy intervals, with 1 to 3 months as the reference group. Association of time to colonoscopy wiGastroenterologyTime to Colonoscopy After Abnormal Stool-Based Screening and Risk for Colorectal Cancer Incidence and Mortality.PMC8096663I01 HX001574CA132379R03CA230947R03 CA230947F32 CA239360R37 CA222866UG3 CA2333145F32CA239360–02UH3 CA233314CA132384U54 CA132379U54 CA132384C19 20-394Martinez MESan Miguel YGupta SMay FPDemb JfalseTime to Colonoscopy After Abnormal Stool-Based Screening and Risk for Colorectal Cancer Incidence and Mortality.<h4>Background and aims</h4>The optimal time interval for diagnostic colonoscopy completion after an abnormal stool-based colorectal cancer (CRC) screening test is uncertain. We examined the association between time to colonoscopy and CRC outcomes among individuals who underwent diagnostic colonoscopy after abnormal stool-based screening.<h4>Methods</h4>We performed a retrospective cohort study of veterans age 50 to 75 years with an abnormal fecal occult blood test (FOBT) or fecal immunochemical test (FIT) between 1999 and 2010. We used multivariable Cox proportional hazards to generate CRC-specific incidence and mortality hazard ratios (HRs) and 95% confidence intervals (CI) for 3-month colonoscopy intervals, with 1 to 3 months as the reference group. Association of time to colonoscopy wi2021-01-01T00:00:00Z2021 May2025-04-27T01:39:13.347Z2025-04-06T18:20:37.315ZS-EPMC80966633354514010.1053/j.gastro.2021.01.219