{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang L"],"funding":["Science and Technology Program of Guangzhou","Traditional Chinese Medicine Research Project of Guangming District","National Natural Science Foundation of China","Shenzhen Healthcare Research Project"],"pagination":["48"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8097947"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["Background
Caloric restriction (CR) has become increasingly attractive in the treatment of type 2 diabetes mellitus (T2DM) because of the increasingly common high-calorie diet and sedentary lifestyle. This study aimed to evaluate the role of CR in T2DM treatment and further explore its potential molecular mechanisms.Methods
Sixty male Sprague-Dawley rats were used in this study. The diabetes model was induced by 8 weeks of high-fat diet (HFD) followed by a single dose of streptozotocin injection (30 mg/kg). Subsequently, the diabetic rats were fed HFD at 28 g/day (diabetic control) or 20 g/day (30% CR regimen) for 20 weeks. Meanwhile, normal rats fed a free standard chow diet served as the vehicle control. Body mass, plasma glucose levels, and lipid profiles were monitored."],"journal":["Nutrition & metabolism"],"pubmed_title":["Protective effects of calorie restriction on insulin resistance and islet function in STZ-induced type 2 diabetes rats."],"pmcid":["PMC8097947"],"funding_grant_id":["81874498","GM2019020022","SZLY2018002","201903010044"],"pubmed_authors":["Li H","Huang YJ","Hu J","Shi XF","Qin J","Ye ZY","Zhang GP","Zhang L","Zhang TY","Liu TL","Sun JP","Ke B"],"additional_accession":[]},"is_claimable":false,"name":"Protective effects of calorie restriction on insulin resistance and islet function in STZ-induced type 2 diabetes rats.","description":"Background
Caloric restriction (CR) has become increasingly attractive in the treatment of type 2 diabetes mellitus (T2DM) because of the increasingly common high-calorie diet and sedentary lifestyle. This study aimed to evaluate the role of CR in T2DM treatment and further explore its potential molecular mechanisms.Methods
Sixty male Sprague-Dawley rats were used in this study. The diabetes model was induced by 8 weeks of high-fat diet (HFD) followed by a single dose of streptozotocin injection (30 mg/kg). Subsequently, the diabetic rats were fed HFD at 28 g/day (diabetic control) or 20 g/day (30% CR regimen) for 20 weeks. Meanwhile, normal rats fed a free standard chow diet served as the vehicle control. Body mass, plasma glucose levels, and lipid profiles were monitored.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2025-04-18T21:43:31.776Z","creation":"2022-02-10T09:32:22.366Z"},"accession":"S-EPMC8097947","cross_references":{"pubmed":["33952301"],"doi":["10.1186/s12986-021-00575-y"]}}