biostudies-literatureZhang LScience and Technology Program of GuangzhouTraditional Chinese Medicine Research Project of Guangming DistrictNational Natural Science Foundation of ChinaShenzhen Healthcare Research Project48https://www.ebi.ac.uk/biostudies/studies/S-EPMC8097947biostudies-literatureUnknown18(1)<h4>Background</h4>Caloric restriction (CR) has become increasingly attractive in the treatment of type 2 diabetes mellitus (T2DM) because of the increasingly common high-calorie diet and sedentary lifestyle. This study aimed to evaluate the role of CR in T2DM treatment and further explore its potential molecular mechanisms.<h4>Methods</h4>Sixty male Sprague-Dawley rats were used in this study. The diabetes model was induced by 8 weeks of high-fat diet (HFD) followed by a single dose of streptozotocin injection (30 mg/kg). Subsequently, the diabetic rats were fed HFD at 28 g/day (diabetic control) or 20 g/day (30% CR regimen) for 20 weeks. Meanwhile, normal rats fed a free standard chow diet served as the vehicle control. Body mass, plasma glucose levels, and lipid profiles were monitored.Nutrition & metabolismProtective effects of calorie restriction on insulin resistance and islet function in STZ-induced type 2 diabetes rats.PMC809794781874498GM2019020022SZLY2018002201903010044Li HHuang YJHu JShi XFQin JYe ZYZhang GPZhang LZhang TYLiu TLSun JPKe BfalseProtective effects of calorie restriction on insulin resistance and islet function in STZ-induced type 2 diabetes rats.<h4>Background</h4>Caloric restriction (CR) has become increasingly attractive in the treatment of type 2 diabetes mellitus (T2DM) because of the increasingly common high-calorie diet and sedentary lifestyle. This study aimed to evaluate the role of CR in T2DM treatment and further explore its potential molecular mechanisms.<h4>Methods</h4>Sixty male Sprague-Dawley rats were used in this study. The diabetes model was induced by 8 weeks of high-fat diet (HFD) followed by a single dose of streptozotocin injection (30 mg/kg). Subsequently, the diabetic rats were fed HFD at 28 g/day (diabetic control) or 20 g/day (30% CR regimen) for 20 weeks. Meanwhile, normal rats fed a free standard chow diet served as the vehicle control. Body mass, plasma glucose levels, and lipid profiles were monitored.2021-01-01T00:00:00Z2021 May2025-04-18T21:43:31.776Z2022-02-10T09:32:22.366ZS-EPMC80979473395230110.1186/s12986-021-00575-y