{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Laskar RS"],"funding":["US National Institutes of Health","Cancer Research UK","World Health Organization","Agence Nationale pour la Recherche","National Cancer Institute","NCI NIH HHS"],"pagination":["343-355"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8098110"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(5)"],"pubmed_abstract":["Sexual dimorphism in cancer incidence and outcome is widespread. Understanding the underlying mechanisms is fundamental to improve cancer prevention and clinical management. Sex disparities are particularly striking in kidney cancer: across diverse populations, men consistently show unexplained 2-fold increased incidence and worse prognosis. We have characterized genome-wide expression and regulatory networks of 609 renal tumors and 256 non-tumor renal tissues. Normal kidney displayed sex-specific transcriptional signatures, including higher expression of X-linked tumor suppressor genes in women. Sex-dependent genotype-phenotype associations unraveled women-specific immune regulation. Sex differences were markedly expanded in tumors, with male-biased expression of key genes implicated in metabolism, non-malignant diseases with male predominance and carcinogenesis, including markers of tumor infiltrating leukocytes. Analysis of sex-dependent RCC progression and survival uncovered prognostic markers involved in immune response and oxygen homeostasis. In summary, human kidney tissues display remarkable sexual dimorphism at the molecular level. Sex-specific transcriptional signatures further shape renal cancer, with relevance for clinical management."],"journal":["Human molecular genetics"],"pubmed_title":["Sexual dimorphism in cancer: insights from transcriptional signatures in kidney tissue and renal cell carcinoma."],"pmcid":["PMC8098110"],"funding_grant_id":["24390","001","ANR-10-INBS-09","U01 CA155309","U01CA155309"],"pubmed_authors":["Robinot N","Mukeria A","Dzamic Z","Scelo G","Chanudet E","Mates D","Holcatova I","Boland A","Foretova L","Hubert JN","Abedi-Ardekani B","McKay JD","Brennan P","Muller DC","Durand G","Le Calvez-Kelm F","Li P","Swiatkowska B","Laskar RS","Deleuze JF","Janout V","Olaso R","Milosavljevic S","Zaridze D","Ecsedi S"],"additional_accession":[]},"is_claimable":false,"name":"Sexual dimorphism in cancer: insights from transcriptional signatures in kidney tissue and renal cell carcinoma.","description":"Sexual dimorphism in cancer incidence and outcome is widespread. Understanding the underlying mechanisms is fundamental to improve cancer prevention and clinical management. Sex disparities are particularly striking in kidney cancer: across diverse populations, men consistently show unexplained 2-fold increased incidence and worse prognosis. We have characterized genome-wide expression and regulatory networks of 609 renal tumors and 256 non-tumor renal tissues. Normal kidney displayed sex-specific transcriptional signatures, including higher expression of X-linked tumor suppressor genes in women. Sex-dependent genotype-phenotype associations unraveled women-specific immune regulation. Sex differences were markedly expanded in tumors, with male-biased expression of key genes implicated in metabolism, non-malignant diseases with male predominance and carcinogenesis, including markers of tumor infiltrating leukocytes. Analysis of sex-dependent RCC progression and survival uncovered prognostic markers involved in immune response and oxygen homeostasis. In summary, human kidney tissues display remarkable sexual dimorphism at the molecular level. Sex-specific transcriptional signatures further shape renal cancer, with relevance for clinical management.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2026-04-18T05:22:29.054Z","creation":"2024-11-21T08:14:23.463Z"},"accession":"S-EPMC8098110","cross_references":{"pubmed":["33527138"],"doi":["10.1093/hmg/ddab031"]}}