{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Feitosa MF"],"funding":["NHLBI","NIA NIH HHS","NIDDK NIH HHS","NIA","NHLBI NIH HHS","NIDDK"],"pagination":["102-110"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8098811"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["297"],"pubmed_abstract":["<h4>Backgrounds and aims</h4>Several genes are known to contribute to the levels and metabolism of HDL-C, however, their protective effects in cardiovascular disease (CVD), healthy aging, and longevity are complex and poorly understood. It is also unclear if these genes predict longitudinal HDL-C change. We aimed to identify loci influencing HDL-C change.<h4>Methods</h4>We performed a genome-wide association study (GWAS) with harmonized HDL-C and imputed genotype in three family-based studies recruited for exceptional survival (Long Life Family Study), from community-based (Framingham Heart Study) and enriched for CVD (Family Heart Study). In 7738 individuals with at least 2 visits, we employed a growth curve model to estimate the random linear trajectory parameter of age-sex-adjusted HDL-"],"journal":["Atherosclerosis"],"pubmed_title":["Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies."],"pmcid":["PMC8098811"],"funding_grant_id":["HHSN268201500001C","R01-DK-089256","U19 AG063893","R01HL117078","P30 DK056341","N01 HC025195","U01AG023746","U01AG023749","U19AG063893","U01 AG023744","U01 AG023755","R01 DK089256","U01 AG023712","U01AG023712","U01AG023744","U01AG023755","R01 HL117078","U01 AG023749","U01 AG023746","HHSN268201500001I","NHLBI-N01-HC25195"],"pubmed_authors":["Christensen K","Murabito JM","Kammerer CM","Province MA","Schupf N","Feitosa MF","Wojczynski MK","Lunetta KL","Perls T","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies.","description":"<h4>Backgrounds and aims</h4>Several genes are known to contribute to the levels and metabolism of HDL-C, however, their protective effects in cardiovascular disease (CVD), healthy aging, and longevity are complex and poorly understood. It is also unclear if these genes predict longitudinal HDL-C change. We aimed to identify loci influencing HDL-C change.<h4>Methods</h4>We performed a genome-wide association study (GWAS) with harmonized HDL-C and imputed genotype in three family-based studies recruited for exceptional survival (Long Life Family Study), from community-based (Framingham Heart Study) and enriched for CVD (Family Heart Study). In 7738 individuals with at least 2 visits, we employed a growth curve model to estimate the random linear trajectory parameter of age-sex-adjusted HDL-","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Mar","modification":"2026-04-08T07:57:42.452Z","creation":"2022-02-10T09:44:03.984Z"},"accession":"S-EPMC8098811","cross_references":{"pubmed":["32109663"],"doi":["10.1016/j.atherosclerosis.2020.02.005"]}}