biostudies-literatureUnknown44(5)Nishimoto KPrimary aldosteronism (PA) is mainly clinically classified as unilateral aldosterone-producing adenoma (APA) or bilateral idiopathic hyperaldosteronism. Immunohistochemistry for aldosterone synthase reveals a diverse PA pathology, including pathological APA and aldosterone-producing cell clusters. The relationship between PA pathology and adrenalectomy outcomes was examined herein. Data from 219 unilaterally adrenalectomized PA cases were analyzed. Pathological analyses revealed diverse putative aldosterone-producing lesions. Postoperative biochemical outcomes in 114 cases (test cohort) were classified as complete success (n = 85), partial success (n = 19), and absent success (n = 10). Outcomes in the large and small PA lesion groups, rather than between PA lesion types, were compared at fHypertension research : official journal of the Japanese Society of Hypertension498-507https://www.ebi.ac.uk/biostudies/studies/S-EPMC8099725biostudies-literatureDiverse pathological lesions of primary aldosteronism and their clinical significance.PMC8099725Suzuki TIchijo TNishimoto KAraki RShibata HKatabami TIzawa SKobayashi HKawamura TTsuiki MMatsuda YFukuoka TYoshiro CSone MKurihara IOgo ANaruse MTanaka YHashimoto SYasuda MFujii YRakugi HMiyauchi SWatanabe MYoshimoto TOtsuki MTakahashi KKamemura KYamamoto KFujita MJRAS Study GroupItoh HSeki TKawashima JYanase TShibayama YKai TYamada MUmakoshi HWada NTakeda YInagaki NOgawa YOkamura SYoshikawa YSakamoto RFukuda HfalseDiverse pathological lesions of primary aldosteronism and their clinical significance.Primary aldosteronism (PA) is mainly clinically classified as unilateral aldosterone-producing adenoma (APA) or bilateral idiopathic hyperaldosteronism. Immunohistochemistry for aldosterone synthase reveals a diverse PA pathology, including pathological APA and aldosterone-producing cell clusters. The relationship between PA pathology and adrenalectomy outcomes was examined herein. Data from 219 unilaterally adrenalectomized PA cases were analyzed. Pathological analyses revealed diverse putative aldosterone-producing lesions. Postoperative biochemical outcomes in 114 cases (test cohort) were classified as complete success (n = 85), partial success (n = 19), and absent success (n = 10). Outcomes in the large and small PA lesion groups, rather than between PA lesion types, were compared at f2021-01-01T00:00:00Z2021 May2025-04-22T02:08:49.992Z2025-04-05T20:12:59.743ZS-EPMC80997253343702710.1038/s41440-020-00579-w