biostudies-literatureTilocca BEuropean Coordinated Research on Long-term Challenges in Information and Communication Sciences &amp; Technologies ERA-NET100253https://www.ebi.ac.uk/biostudies/studies/S-EPMC8100217biostudies-literatureUnknown13Brucellosis caused by <i>Brucella melitensis</i> is a zoonosis frequently reported in the Mediterranean and Middle-East regions and responsible for important economic losses and reduced animal welfare. To date, current strategies applied to control or eradicate the disease relies on diagnostic tests that suffer from limited specificity in non-vaccinated animals; while prophylactic measures, when applied, use a live attenuated bacterial strain characterized by residual virulence on adult pregnant animals and difficulties in distinguishing vaccinated from infected animals. To overcome these issues, studies are desired to elucidate the bacterial biology and the pathogenetic mechanisms of both the vaccinal strain and the pathogenic strains. Proteomics has a potential in tackling issues of One-One health (Amsterdam, Netherlands)Comparative proteomics of <i>Brucella melitensis</i> is a useful toolbox for developing prophylactic interventions in a One-Health context.PMC8100217618127Tittarelli MPaci VTilocca BUrbani AGarofolo GSoggiu AGreco VBonizzi LRoncada PSacchini FfalseComparative proteomics of <i>Brucella melitensis</i> is a useful toolbox for developing prophylactic interventions in a One-Health context.Brucellosis caused by <i>Brucella melitensis</i> is a zoonosis frequently reported in the Mediterranean and Middle-East regions and responsible for important economic losses and reduced animal welfare. To date, current strategies applied to control or eradicate the disease relies on diagnostic tests that suffer from limited specificity in non-vaccinated animals; while prophylactic measures, when applied, use a live attenuated bacterial strain characterized by residual virulence on adult pregnant animals and difficulties in distinguishing vaccinated from infected animals. To overcome these issues, studies are desired to elucidate the bacterial biology and the pathogenetic mechanisms of both the vaccinal strain and the pathogenic strains. Proteomics has a potential in tackling issues of One-2021-01-01T00:00:00Z2021 Dec2026-04-07T15:12:57.504Z2022-02-10T10:36:53.405ZS-EPMC81002173399723710.1016/j.onehlt.2021.100253