biostudies-literatureUnknown77(Pt 5)Naghiyev FNRUDN University Strategic Academic Leadership ProgramBaki Dövl\#601;t UniversitetiIn the mol-ecular structure of the title compound, C₁₆H₁₃Cl₂N₅, the 1,4-di-hydro-pyridine ring of the 1,3,4,8-tetra-hydro-2<i>H</i>-pyrido[1,2-<i>a</i>]pyrimidine ring system adopts a screw-boat conformation, while the 1,3-diazinane ring is puckered. In the crystal, inter-molecular N-H⋯N and C-H⋯N hydrogen bonds form mol-ecular sheets parallel to the (110) and (10) planes, crossing each other. Adjacent mol-ecules are further linked by C-H⋯π inter-actions, which form zigzag chains propagating parallel to [100]. A Hirshfeld surface analysis indicates that the most significant contributions to the crystal packing are from N⋯H/H⋯N (28.4%), H⋯H (24.5%), C⋯H/H⋯C (21.4%) and Cl⋯H/H⋯Cl (16.1%) contacts.Acta crystallographica. Section E, Crystallographic communications516-521https://www.ebi.ac.uk/biostudies/studies/S-EPMC8100256biostudies-literatureCrystal structure and Hirshfeld surface analysis of 6-amino-8-(2,6-di-chloro-phen-yl)-1,3,4,8-tetra-hydro-2<i>H</i>-pyrido[1,2-<i>a</i>]pyrimidine-7,9-dicarbo-nitrile.PMC8100256Naghiyev FNAkkurt MKhrustalev VNTereshina TAAkobirshoeva AARzayev RMMamedov IGfalseCrystal structure and Hirshfeld surface analysis of 6-amino-8-(2,6-di-chloro-phen-yl)-1,3,4,8-tetra-hydro-2<i>H</i>-pyrido[1,2-<i>a</i>]pyrimidine-7,9-dicarbo-nitrile.In the mol-ecular structure of the title compound, C₁₆H₁₃Cl₂N₅, the 1,4-di-hydro-pyridine ring of the 1,3,4,8-tetra-hydro-2<i>H</i>-pyrido[1,2-<i>a</i>]pyrimidine ring system adopts a screw-boat conformation, while the 1,3-diazinane ring is puckered. In the crystal, inter-molecular N-H⋯N and C-H⋯N hydrogen bonds form mol-ecular sheets parallel to the (110) and (10) planes, crossing each other. Adjacent mol-ecules are further linked by C-H⋯π inter-actions, which form zigzag chains propagating parallel to [100]. A Hirshfeld surface analysis indicates that the most significant contributions to the crystal packing are from N⋯H/H⋯N (28.4%), H⋯H (24.5%), C⋯H/H⋯C (21.4%) and Cl⋯H/H⋯Cl (16.1%) contacts.2021-01-01T00:00:00Z2021 May2026-04-19T03:18:54.157Z2026-04-19T03:09:23.046ZS-EPMC81002563402625610.1107/S2056989021003583