biostudies-literatureHui DNINR NIH HHSNational Cancer InstituteNCI NIH HHSNational Institutes of HealthAndrew Sabin Family Fellowship Awarde883-e892https://www.ebi.ac.uk/biostudies/studies/S-EPMC8100563biostudies-literatureUnknown26(5)<h4>Background</h4>The effect of high-flow oxygen (HFOx) and high-flow air (HFAir) on dyspnea in nonhypoxemic patients is not known. We assessed the effect of HFOx, HFAir, low-flow oxygen (LFOx), and low-flow air (LFAir) on dyspnea.<h4>Subjects, materials, and methods</h4>This double-blind, 4×4 crossover clinical trial enrolled hospitalized patients with cancer who were dyspneic at rest and nonhypoxemic (oxygen saturation >90% on room air). Patients were randomized to 10 minutes of HFOx, HFAir, LFOx, and LFAir in different orders. The flow rate was titrated between 20-60 L/minute in the high-flow interventions and 2 L/minute in the low-flow interventions. The primary outcome was dyspnea numeric rating scale (NRS) "now" where 0 = none and 10 = worst.<h4>Results</h4>Seventeen patients (mean The oncologistHigh-Flow Oxygen and High-Flow Air for Dyspnea in Hospitalized Patients with Cancer: A Pilot Crossover Randomized Clinical Trial.PMC8100563P30CA016672P30 CA016672R21 NR0167361R01CA214960-01A1R01 CA225701R01 CA214960Hernandez FElsayem AThomas SLu ZBruera EHui DUrbauer DfalseHigh-Flow Oxygen and High-Flow Air for Dyspnea in Hospitalized Patients with Cancer: A Pilot Crossover Randomized Clinical Trial.<h4>Background</h4>The effect of high-flow oxygen (HFOx) and high-flow air (HFAir) on dyspnea in nonhypoxemic patients is not known. We assessed the effect of HFOx, HFAir, low-flow oxygen (LFOx), and low-flow air (LFAir) on dyspnea.<h4>Subjects, materials, and methods</h4>This double-blind, 4×4 crossover clinical trial enrolled hospitalized patients with cancer who were dyspneic at rest and nonhypoxemic (oxygen saturation >90% on room air). Patients were randomized to 10 minutes of HFOx, HFAir, LFOx, and LFAir in different orders. The flow rate was titrated between 20-60 L/minute in the high-flow interventions and 2 L/minute in the low-flow interventions. The primary outcome was dyspnea numeric rating scale (NRS) "now" where 0 = none and 10 = worst.<h4>Results</h4>Seventeen patients (mean 2021-01-01T00:00:00Z2021 May2025-04-26T20:06:19.114Z2022-02-10T09:56:06.271ZS-EPMC81005633328927610.1002/onco.13622