biostudies-literatureUnknown10(4)Barbosa LOPseudoangiosarcomatous squamous cell carcinoma, also called pseudovascular, pseudoangiomatoid or adenoid pseudovascular carcinoma, is an uncommon and highly aggressive variant of squamous cell carcinoma. Histologically, it is characterized by proliferation of atypical keratinocytes with acantholysis and formation of pseudovascular spaces, forming anastomosed channels lined with neoplastic cells that invade the dermis. These cells are positive for cytokeratin and negative for vascular markers such as CD31 and CD34. There are few reports of this variant in the literature. Skin, breast, lung and vulva involvement have been described, but to the best of our knowledge, no cases involving the penis has been described. This study aims to describe the first case of angiosarcomatous squamous cell cTranslational andrology and urology1803-1806https://www.ebi.ac.uk/biostudies/studies/S-EPMC8100835biostudies-literaturePseudoangiosarcomatous squamous cell carcinoma: first case report on penis.PMC8100835Neto JOBCalixto JRRPinho JDBarbosa LOdo Nascimento FSMSda C Melo SPTeixeira-Junior AALNogueira LRCunha IWSoares FASilva GEBfalsePseudoangiosarcomatous squamous cell carcinoma: first case report on penis.Pseudoangiosarcomatous squamous cell carcinoma, also called pseudovascular, pseudoangiomatoid or adenoid pseudovascular carcinoma, is an uncommon and highly aggressive variant of squamous cell carcinoma. Histologically, it is characterized by proliferation of atypical keratinocytes with acantholysis and formation of pseudovascular spaces, forming anastomosed channels lined with neoplastic cells that invade the dermis. These cells are positive for cytokeratin and negative for vascular markers such as CD31 and CD34. There are few reports of this variant in the literature. Skin, breast, lung and vulva involvement have been described, but to the best of our knowledge, no cases involving the penis has been described. This study aims to describe the first case of angiosarcomatous squamous cell c2021-01-01T00:00:00Z2021 Apr2025-04-27T00:16:36.806Z2025-04-06T17:46:42.616ZS-EPMC81008353396866810.21037/tau-20-1234